Crosslinked hydrogel compositions with improved mechanical perfo

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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524916, 536 21, 536102, 536106, 536114, 5361231, 53612312, 536124, 623 1, 623 12, 623900, 424422, 424423, 424488, C08L 508, A61M 2500

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055413048

ABSTRACT:
This invention provides a method of altering the water content of a hydrogel comprising treatment of said hydrogel with a liquid dehydrating composition. There is further provided a method of altering the water content of a hydrogel-containing medical device. The medical devices of the present invention comprise a hydrogel having a water level ex vivo lower than the thermodynamic equilibrium water level when in vivo. These medical devices comprise a hydrogel contacted with a liquid dehydrating agent, wherein said medical device has a lower water level ex vivo than the thermodynamic equilibrium water level when the medical device is in vivo.

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