Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-05-08
1988-10-11
Brown, J. R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530402, 530408, 530409, 530410, 424101, C07K 308, C07K 1522
Patent
active
047772441
ABSTRACT:
Crosslinked hemoglobin preparations of extended shelf life and high oxygen transport capacity can be made by reducing a hemoglobin solution with an oxygen consuming reducing agent down to an oxygen partial pressure of 0 mbar, then adding an effector, crosslinking with a dialdehyde, reducing with a carbonyl-group-specific reducing agent, circulating through an ultrafilter, and stabilizing the product by adding a reducing agent thereto.
REFERENCES:
patent: 4061736 (1977-12-01), Morris et al.
patent: 4136093 (1979-01-01), Bonhard et al.
Characterization of a Modified, Stroma-Free . . . , N. Kothe et al. Gyn. & Obs., Dec. 1985, vol. 161, pp. 563-569.
Abstract 428 Methemoglobin Accumulation in Minnesota Hemoglobin, C. Drayton et al., (1982).
Bonhard Klaus
Kothe Norbert
Biotest-Serum-Institut GmbH
Brown J. R.
Stone Jacqueline M.
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