Crosslinked antibodies and processes for their preparation

Details Crosslinked antibodies and processes for their preparation Crosslinked antibodies and processes for their preparation

1992-01-22

1994-10-11

Kim, Kay K.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 153, 424 9, 424 943, 4241781, 4241791, 5303911, 5303913, 5303915, 5303917, 5303919, 436544, 436545, 436546, 435188, A61K 3944, A61K 4902, C07K 1702

Patent

active

053545540

ABSTRACT:
Cross-linked labelled antibody conjugates are described which have at least one non-disulphide interchain bridge. The bridge may be the residue of a homo- or heterofunctional cross-linking reagent, and is located away from the antigen binding domains of the antibody. The antibody conjugates have an enhanced binding capacity and in vivo have good blood clearance and, in the presence of a tumour high tumour: blood and tumour: bone ratios. The conjugates are of use in the diagnosis and therapy of e.g. tumours and may be prepared by reaction of a cross-linking reagent with an antibody.

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