Crosslinked antibodies and processes for their preparation

Details Crosslinked antibodies and processes for their preparation Crosslinked antibodies and processes for their preparation

1994-09-30

1998-02-03

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424 111, 424 149, 4241301, 4241411, 435972, 5303911, 5303919, A61K 39395, A61K 5100, G01N 3353, C07K 1600

Patent

active

057141495

ABSTRACT:
Cross-linked antibody conjugates are described which have at least one interchain bridge containing a reporter or effector molecule. The bridge may be the residue of a homo-or heterofunctional cross-linking reagent, and is located away from the antigen binding domains of the antibody. The antibody conjugates have an enhanced binding capacity and in vivo have good blood clearance and, in the presence of a tumour high tumour; blood and tumour; bone ratios. The conjugates are of use in the diagnosis and therapy of e.g. tumours and may be prepared by reaction of a cross-linking reagent with an antibody.

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Roitt, et al., Immunology, Gower Publishing, London, England, pp. 5.6-5.7, 1985.

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