Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-02-06
1995-09-26
Acquah, Samuel A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
424 781, 424 7812, 424497, 522173, 526310, 5263285, 514554, 514570, A01N 4342
Patent
active
054534291
ABSTRACT:
New bile acid sequestrant polymer compositions and a process for preparing the polymers in particulate form, preferably in spherical form, are described. The polymer particles are prepared by crosslinking an amine-containing polymer with an amount of a polyfunctional amine-reactive compound sufficient to crosslink the polymer so that it is essentially water insoluble and has bile acid sequestering efficacy greater than that of cholestyramine, preferably greater than about three times the efficacy of cholestyramine. A preferred polymerization process involves suspension polymerization of water-soluble amine-containing monomers, such as dialkylaminoalkyl (meth)acrylate esters and dialkylaminoalkyl (meth)acrylamides, in the presence of polyfunctional amine-reactive compounds, such as substituted dihaloalkanes. Pharmaceutical compositions containing the bile acid sequestrant polymer particles and a method for lowering blood cholesterol levels using the pharmaceutical compositions are also described.
REFERENCES:
patent: 3383281 (1968-05-01), Wolf et al.
patent: 3692895 (1972-09-01), Nelson et al.
patent: 4046750 (1977-09-01), Rembaum
Bliem Paul E.
Steffier Larry W.
Acquah Samuel A.
Howell Thomas J.
Rohm and Haas Company
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