Crosslinkable macromers

Details Crosslinkable macromers Crosslinkable macromers

2006-08-22

2006-08-22

Russel, Jeffrey E. (Department: 1654)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S445000, C424S486000, C424S488000, C602S048000, C602S049000, C602S050000, C602S054000, C623S001360, C623S023590, C623S023600, C623S920000, C623S921000, C623S923000, C623S926000

Reexamination Certificate

active

07094418

ABSTRACT:
A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.

REFERENCES:
patent: 3879353 (1975-04-01), Crawford
patent: 4315998 (1982-02-01), Neckers et al.
patent: 4477326 (1984-10-01), Lin
patent: 4594400 (1986-06-01), Kvita et al.
patent: 4758611 (1988-07-01), Beers
patent: 5118779 (1992-06-01), Szycher
patent: 5213580 (1993-05-01), Slepian et al.
patent: 5232984 (1993-08-01), Hubbell et al.
patent: 5334640 (1994-08-01), Desai et al.
patent: 5380536 (1995-01-01), Hubbell et al.
patent: 5391406 (1995-02-01), Ramharack et al.
patent: 5410016 (1995-04-01), Hubbell et al.
patent: 5527925 (1996-06-01), Chabrecek et al.
patent: 5529914 (1996-06-01), Hubbell et al.
patent: 5552452 (1996-09-01), Khadem et al.
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5575815 (1996-11-01), Slepian et al.
patent: 5612050 (1997-03-01), Rowe et al.
patent: 5723513 (1998-03-01), Bonham et al.
patent: 5843156 (1998-12-01), Slepian et al.
patent: 5846530 (1998-12-01), Soon-Shiong et al.
patent: 5858746 (1999-01-01), Hubbell et al.
patent: 5900245 (1999-05-01), Sawhney et al.
patent: 6007833 (1999-12-01), Chudzik
patent: 6093302 (2000-07-01), Montgomery
patent: 6156345 (2000-12-01), Chudzik
patent: 6410044 (2002-06-01), Chudzik
patent: 6924370 (2005-08-01), Chudzik et al.
patent: 0 169 001 (1986-01-01), None
patent: WO 93/16687 (1993-09-01), None
patent: WO 96/40829 (1996-12-01), None
patent: WO 97/24376 (1997-07-01), None
“Radical Polymerization”, C.H. Bamford, pp. 940-957 in Kroschwitz, ed., Concise Encyclopedia of Polymer Science and Engineering, 1990.

Affiliated with

Also associated with

Rating

Crosslinkable macromers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crosslinkable macromers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crosslinkable macromers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3664216