Crossed immunoelectrophoretic technique for predicting Down's sy

Details Crossed immunoelectrophoretic technique for predicting Down's sy Crossed immunoelectrophoretic technique for predicting Down's sy

1985-05-21

1989-04-04

Rosen, Sam

Chemistry: analytical and immunological testing

Involving diffusion or migration of antigen or antibody

Through a gel

G01N 33561

Patent

active

048187089

ABSTRACT:
An improved crossed electrophoretic technique is disclosed, which is especially adapted for detecting the presence in serum of a protein associated with parenting a Down's syndrome child. The improved technique comprises reducing the second dimension gel antiserum concentration and increasing the second dimension voltage, to be within certain limits.

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G. Kwapinski, Methodology of Investigative and Clinical Immunology, Robert E. Krieger Publishing Co., Inc., Malabar, FL, 1982, pp. 306-310.
O. Ouchterlony et al., in D. M. Weir (Ed), Handbook of Experimental Immunology--3rd Ed., Blackwell Scientific Pub., Oxford, 1978, p. 19.31.
J. Nedziora et al., Experientia, 36, 926-927, 1980.
J. F. Monthony et al., Clin. Chem., 24, 1925-1827, 1978.
B. Weeke, Scand Journ Immunol, 2 (Suppl 1), 47-56, 1973.
J. Kerkay et al., American Journ. Ment. Defil., 75, 729-732, 1971.

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