Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2001-10-09
2003-11-25
Dodson, Shelle A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C424S059000, C424S060000, C424S195110, C424S400000, C424S401000, C514S492000, C514S499000, C514S505000, C514S720000, C514S733000
Reexamination Certificate
active
06653327
ABSTRACT:
BACKGROUND OF THE INVENTION
Turmeric-Derived Phenolic Compounds in Skin Protection
The role of curcuminoids, yellow phenolic compounds derived from turmeric roots (
Curcuma longa
, fam. Zingiberaceae), as topical antioxidants has been traditionally known in Asia and recently validated in laboratory experiments. Curcuminoids are reported to protect normal human keratinocytes from hypoxanthine/xanthine oxidase injury in in vitro studies, and they can protect the skin against a broad range of physical, chemical and biological factors injuring the skin
1
. Free radicals on the surface of the skin, generated through exposure to ultraviolet radiation, especially the UVB rays, chemicals or other environmental stress factors catalyze aging of the skin. Curcuminoids prevent free radical formation and scavenge free radicals in biological systems. This combined action was previously described as a Bioprotectant mechanism that protects the integrity of the living cell e.g. skin cell. The antioxidant effects of curcuminoids combined with their known inhibitory effects on cyclooxygenase 2 (Cox-2) render them useful as ingredients in anti-aging formulations and in topical formulations designed to maintain general skin health and integrity. Curcuminoids have also been found to inhibit the activity of tyrosinase, an enzyme that participates in melanogenesis, thereby preventing melanin formation with resultant lightening of the skin tone.
2
Tetrahydrocurcuminoids (THC) are color-free compounds derived from curcuminoids, the yellow, parent compounds of THC, in the process of hydrogenation. The process of hydrogenation of curcuminoids can also occur naturally in the gastrointestinal tract.
3
The tetrahydrocurcuminoids' similar biological properties to curcuminoids combined with the lack of yellow color, render them useful in achromatic food and cosmetic applications that currently employ conventional synthetic antioxidants.
Like the curcuminoids, THC have also shown significant antioxidant action in a number of in vitro and preclinical studies.
4-9
THC are valued as the ultimate metabolites of the curcuminoids in vivo. Several independent studies validated the significant antioxidant effects of the tetrahydrocurcuminoids and protection of skin against free radicals and UVB rays.
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patent: WO 99/55352 (1999-11-01), None
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Venkateswarlu, S. et al. “Synthesis and Antibacterial Activity of Tetrahydrocurcuminoids”, Asian Journal of Chemistry (2000); 12(1):141-144.
Osawa, T. et al. “Antioxidative Activity of Tetrahydrocurcumin”, International Congress Series (1992), vol. 998, pp. 801-804.
Kobe Steel, “External Agent for Preventing UV Damage and Rough Skin-Contains Tetrahydro-curcumin Prepared by Reducing Curcumin Extracted from Turmeric Root”, Derwent Publications Ltd., London, GB; AN 1994-188874; English Abstract of JP 06 128133.
Patent Abstracts of Japan, Publication No.: 06-128133, Published Oct. 5, 1994 and Derwent Abstract; WPI Acc. No.: 1994-188874/199423; for JP 6128133.
Walker, M.J. et al. “Curcumin in a Chemoprevention Model of Melanoma”, Proceedings of the American Association for Cancer Research Annual Meeting (Mar. 1998) vol. 39, p. 19.
Ruby, A.J. et al. “Anti-tumor and antioxidant activity of natural curcuminoids”, Cancer Letters (1995); 94:79-83.
Menon, L.A. et al. “Anti-metastatic activity of curcumin and catechin”, Cancer Letters (1999); 141:159-165.
Menon, L.G. et al. “Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds”, Cancer Letters (1995); 95:221-225.
Mulky, N. et al. “Antimutagenicity of Curcumins and Related Compounds: The Structural Requirement for the Antimutagenicity of Curcumins”, Indian Drugs (1987); 25(3):91-95.
Nagabhushan, M. et al. “Curcumins as Inhibitors of Nitrosation in vitro”, Mutation Research (1988); 202:163-169.
Sharma, O.P. “Antioxidant Activity of Curcumin and Related Compounds”, Biochemical Pharmacology (1976); 25(15):1811-1812.
Badmaev Vladimir
Majeed Muhammed
Arent Fox Kintner & Plotkin & Kahn, PLLC
Dodson Shelle A.
Sabinsa Corporation
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