Cross-reactive influenza a immunization

Details Cross-reactive influenza a immunization Cross-reactive influenza a immunization

1995-04-07

1998-06-16

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242041, 4242051, 4241841, A61K 3112, A61K 39145, A61K 3900, A61K 3938

Patent

active

057666016

ABSTRACT:
This disclosure relates to methods and compositions for stimulating in an individual an influenza A virus protective response which is subtype cross-protective. Influenza A virus NS1 protein, or a T cell epitope thereof, is administered to the individual in an amount sufficient to stimulate the virus protective response.

REFERENCES:
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Bennink, et al, 1987, Anh-Influenza virus cytotoxic T Iymphocytes. . . J. Virol. 61(4):1098-1102.
Kuwano, Koichi et al., "Cross-Reactive Protection against Influenza A Virus Infections," Virology,178 :174-179 (1990).
Cossins Judy et al., "Precise Prediction of a K.sup.k -Restricted Cytotoxic T Cell Epitope in the NS1 Protein of Influenza Virus Using an MHC Allele-Specific Motif," Virology,193 (1) :289-295 (1993).
Hackett, Charles J. et al. "Influenza virus infection elicits class II major histocompatibility complex-restricted T cells specific for an epitope indentified in the NS1 non-structural protein," J. of General Virology,73:1339-1343 (1992).

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