Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1994-06-14
1997-04-22
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241521, 4241721, 4241431, 4241731, 435 7021, 4351722, 435334, 435343, 536 2353, 5303871, 5303873, 5303881, 53038822, 5303887, 5303896, A61K 39395, C07K 1628, C12N 512, C12N 1513
Patent
active
056227019
ABSTRACT:
The invention provides monoclonal antibodies that specifically bind to P-selectin and to E-selectin. Many of the antibodies block the functional interactions of P-selectin and E-selectin with the irrespective counterreceptors.
REFERENCES:
patent: 5225539 (1993-07-01), Winter
Abbassi et al., "Canine neutrophil margination mediated by lectin adhesion molecule-1 in vitro," J. Immunol. 147:2107-2115 (1991).
Jutila et al., "Characterization of a functionally important and evolutionarily well-conserved epitope mapped to the short consensus repeats of E-selectin and L-selectin", J. Exp. Med. 175:1565-1573 (1992).
"Antibodies," Excerpt, R&D Systems 1993 Catalog, Minneapolis, MN.
"Adhesion Molecule Antibodies," Excerpt, R&D Systems 1994 Catalog, Minneapolis, MN.
Emery et al. Humanised mAb for Therapeutic application, Eap Opin Invest Drugs 1994 3:241-51.
Cunningham et al. Anitbody engineering--how to be human TIBTECH Apr. 1992.
Berg et al. Comparison of L-selectin & E-selectin ligand specificitiy. The L-selectin can bind The E-selectin ligands sialyl Le.sup.x + Le.sup.a Biochem & Biophys. Res. Comm. 184:1048:55 1992.
Seekamp et al. Role of selectins in local & remote tissue injury following ischemia & reperfusion. Amer. J. Path. 144:592-98 1994.
Greaing et al. Circulating adhesion molecules in disease Immunol. Today 17:506-12 1993.
Erbe et al. P-+E-selectin use common sites for carbohydrate ligand recognition & cell adhesion. J. Cell Biol. 120:1227-35 1993.
Goding Monoclonal antibodies: Principles & practice Prod. & application of mAb in cell Biol. Biochem. & immunol. 1986
Kearney Hybridomas & MAb. Fundamental. Immunol. 1984 751-66.
McDougal et al. Binding of The human retrovirus HTLV -III/LAV/ARV/HIV to the (by cty) molecule: Conformation Dependences, epitope mapping antibody inhibition, and potential for idio topic memory J. Immunol. 137:2937 1986.
Berg et al. Blood 85: 31-37 (1995).
Larsen et al. J Biol. Chem. 267:11104-11110 (1992).
Weitz-Schmidt et al. in Leukocyte Typing 5 Schlossman et al. (Eds.) Oxford University Press 1995 Chapter E6.24, pp. 1839-1840.
Lefer et al. Cardiovascular Research 28: 289-294(1994).
Chan Christina Y.
Gambel Phillip
Protein Design Labs, Inc.
LandOfFree
Cross-reacting monoclonal antibodies specific for E- and P-selec does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cross-reacting monoclonal antibodies specific for E- and P-selec, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cross-reacting monoclonal antibodies specific for E- and P-selec will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-339785