Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-09-02
1998-02-10
Loring, Susan A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303881, 53038815, 5303884, 4241421, 4241371, 4241501, 435329, 435340, C07K 618, C07K 1612, C12N 522, A61K 3940
Patent
active
057170711
ABSTRACT:
Cell lines have been produced that secrete human monoclonal antibodies capable of binding to molecules of different bacterial species. These antibodies have been found to be protective against lethal challenges of various bacterial genera. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included. Prior to filing of this patent application the continuous transformed human cell lines 9B10, 4F10, 4B9, 7D7, and 9C3, described herein, were deposited in the American Type Culture Collection and given the designations CRL 9006, CRL 9007, CRL 9008, CRL 9009, and CRL 9239, respectively.
REFERENCES:
patent: 4464465 (1984-08-01), Lostrom
patent: 4587121 (1986-05-01), Collins et al.
patent: 4675287 (1987-06-01), Reisfeld et al.
patent: 4677070 (1987-06-01), Larrick et al.
patent: 4734279 (1988-03-01), Stephan et al.
patent: 4772464 (1988-09-01), Rutherford
patent: 4777136 (1988-10-01), Young
patent: 4834975 (1989-05-01), Siadak et al.
patent: 5378812 (1995-01-01), Siadak et al.
Moreno, C. et al."Immunological Properties of Monoclonal Antibodies Specific for Meningococcal Polysaccharides: the Protective Capacity of IgM Antibodies Specific for Polysaccharide Group B," J. Gen. Microbiol. 129:2451-2456, 1983.
Hiernaux, J.R. et al. "Study of the Idiotypy of Lipopoly-saccharide-specific Polyclonal and Monoclonal Antibodies," Eur. J. Immunol. 12:797-803, 1982.
Pluschke, G. et al. "Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis and Monoclonal Antibodies as Tools for the Subgrouping of Escherichia coli Lipopdysaccharide 018 and 023 Antigens," Infection and Immunity 51(1):286-293, Jan. 1986.
Sorensen, R.U. et al. "Defective Cellular Immunity to Gram-Negative Bacteria in Cystic Fibrosis Patients," Infection and Immunity 23:398-402, Feb. 1979.
Sugasawara, R.J. et al. "Monoclonal Antibodies Against Neisseria meningitidis Lipopolysaccharide" Infection and Immunity 43(3):863-868, Dec. 1983.
Egan, M.L.,et al., 1983, J. Exp. Med., 1:1006-1011.
Mayer, et al., 1985, Meths. Microbiology, 18:157-201.
Sakulramrung and Domingue, 1985, J. Infect. Dis., 151:995-1104.
McCabe, et al., 1977, J. Infect. Dis., 136S:161-166.
Mullan, et a., 1974, Infect. Immun., 10:1195-1201.
Elkins and Metcalf, 1985, Infect. Immun. 48:597-600.
Gigliotti and Shenep, 1985, J. Infect. Dis. 151:1005-1011.
U.S.S.N. 807,364, 1985,pp. 1-36.
Gigliotti and Shenep, 1985, J. Infect. Dis., 122:100-103.
Frosch, M., et al., 1985, Proc. Natl. Acad. Sci. USA, 82:1194-1198.
Guerina, et al., 1983, J. Infect. Dis., 148:395-405.
Zollinger, et al., 1983, Infect. Immun. 40:257-264.
Abraham, et al., 1985, Infect. Immun. 48:625-628.
Collins, et al., 1984, Am. J. Med. 76:155-160.
Teng, et al., 1985, Proc. Natl. Acad. Sci. U.S.A. 82:1790-1794.
Hornberger, et al., 1985, Fed. AM. Soc. Exp. Biol., 69th Ann. Meet., Abst. No. 5366.
Kirkland, et al., 1984, J. Immunol. 132:2590-2592.
Cryz, et al., 1984, Infect. Immun. 45:139-142.
Gigliotti, et al., 1984, J. Infect. Dis. 149:43-47.
Hunter, Jr., et al., 1984, New Horiz. Microbiology, pp. 99-106.
Artenstein, et al., 1975, New Approaches for Inducing Natural Immunity to Pyogenic Organisms, pp. 57-58.
Robbins, et al., 1975, New Approaches for Inducing Natural Natural Immunity to Pyogenic Organisms, pp. 59-62.
Givner, et al., 1985, J. Infect. Dis. 151:217-220.
Ruch, Jr., et al., 1982, J. Clin. Microbiol. 16:145-152.
Baltimore, et al., 1979, J. Infect. Dis. 140:81-88.
Finne, et al., 1983, Lancet 2:355-357.
Kasper, et al., 1973, J. Immunol. 110:262-268.
Verhoef, et al., Eur. J. Clin Microbiol. Infect. Dis, 9(4):247-250, Apr. 1990.
Ceriani, R.L. et al., Proceedings of the Int. Workshop on Monoclonal Antibodies & Breast Cancer, pp. 248-268, Nov. 8-9, 1984.
Spalding, B.J., Bio/Technology, 11:428-429, Apr. 1993.
Stone, R., Science, 259:1243, 26 Feb. 1993.
Fitzer-Schiller, G., The Washington Post, D3, Jan. 19, 1993.
Harris, W.J., et al, TiBTECH, 11:42-44, 1993.
Waldmam, T.A., Science, 252:1657-1662, Jun. 1991.
Osband, M.E. et al., Immunology Today, 11(6):193-195, 1990.
Wilkinson, S.G., "Surface Carbohydrates of the Probaryotic Cell", pub. Academic Press Inc, pp. 97-171, 1977.
Cross, A.S., et al., 1983, J. Infect. Dis., 147:68-76.
Soderstrom, T., et al., 1983, Prog. Allergy 33:259-274.
Cross, A.S., et al., 1984, J. Infect. Dis., 149:184-193.
Bristol--Myers Squibb Company
Loring Susan A.
LandOfFree
Cross-protective human monoclonal antibody compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cross-protective human monoclonal antibody compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cross-protective human monoclonal antibody compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2078259