Cross-linking protein compositions having two or more identical

Details Cross-linking protein compositions having two or more identical Cross-linking protein compositions having two or more identical

Filed on

1990-04-09

Date issued

1993-02-09

Examiner

Nucker, Christine M.

Patent Class

Chemistry: natural resins or derivatives; peptides or proteins;

SubClass

Proteins, i.e., more than 100 amino acid residues

SubSubClass

Blood proteins or globulins, e.g., proteoglycans, platelet...

Other Related Categories

5303873, 5303913, 5303915, 5303917, 5303919, 530403, 530408, 530409, 424 858, 424 8591, 435972, 436512, 436547, 436819, C07K 1706, C07K 1528, A61K 3944

Type

Patent

Status

active

Patent number

051854333

Description

ABSTRACT:
The present invention provides cross-linked protein compositions consisting of two or more units of a target-specific protein joined by binding sulfhydryl groups on the target-specific protein units to a sulfhydryl-selective cross-linking agent and a method of making the compositions. These cross-linked protein compositions combine an increase in binding affinity due to the presence of multiple identical binding sites and stability to reduction conditions.

REFERENCES:
patent: 4433059 (1984-02-01), Chang et al.
patent: 4507234 (1985-03-01), Kato et al.
patent: 4659839 (1987-04-01), Nicolotti et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4676980 (1987-06-01), Segal et al.
patent: 4698420 (1987-10-01), Urnovitz
patent: 4751286 (1988-06-01), Packard et al.
Glennie et al (1987) J. Immunol. 139: 2367-2375.
Brennan et al (1985) Science 229:81-83.
Liu et al (1985) Proc. Natl. Acad. Sci. USA 82:8648-8652.

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