Cross-linking protein compositions having two or more identical

Details Cross-linking protein compositions having two or more identical Cross-linking protein compositions having two or more identical

1990-04-09

1993-02-09

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303873, 5303913, 5303915, 5303917, 5303919, 530403, 530408, 530409, 424 858, 424 8591, 435972, 436512, 436547, 436819, C07K 1706, C07K 1528, A61K 3944

Patent

active

051854333

ABSTRACT:
The present invention provides cross-linked protein compositions consisting of two or more units of a target-specific protein joined by binding sulfhydryl groups on the target-specific protein units to a sulfhydryl-selective cross-linking agent and a method of making the compositions. These cross-linked protein compositions combine an increase in binding affinity due to the presence of multiple identical binding sites and stability to reduction conditions.

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patent: 4671958 (1987-06-01), Rodwell et al.
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Glennie et al (1987) J. Immunol. 139: 2367-2375.
Brennan et al (1985) Science 229:81-83.
Liu et al (1985) Proc. Natl. Acad. Sci. USA 82:8648-8652.

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