Cross-linking oligonucleotides

Details Cross-linking oligonucleotides Cross-linking oligonucleotides

1994-11-04

1998-10-20

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 245, C07H 1904, C07H 2100, C07H 2102, C07H 2104

Patent

active

058247963

ABSTRACT:
This invention is directed to novel substituted nucleotide bases with a crosslinking arm which accomplish crosslinking between specific sites on adjoining strands of oligonucleotides or oligodeoxynucleotides. The invention is also directed to oligonucleotides comprising at least one of these crosslinking agents and to the use of the resulting novel oligonucleotides for diagnostic and therapeutic purposes. The crosslinking agents of the invention are of the following formula (I'):

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