Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...
Reexamination Certificate
2005-07-05
2005-07-05
Tate, Christopher R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
C530S391100, C540S456000, C540S462000, C546S278400, C546S278700
Reexamination Certificate
active
06913748
ABSTRACT:
Disclosed is a method of making conjugates of cell binding agents and small molecule drugs comprising reacting a cell binding agent with a bifunctional cross-linking moiety to thereby provide the cell binding agent with a reactive disulfide group and then reacting the modified cell binding agent with a small molecule drug comprising a free thiol group. Bifunctional cross-linking moieties are also disclosed.
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Yokoyama et al, Makromol. Chem, 190, 2041-2054 (1989).
Yokoyama et al. “Molecular design for missile drug: Synthesis of adriamycin conjugated with immunoglobulin G using poly(ethylene glycol-block-(aspartic acid) as intermediate carrier.” Makromol. Chem. 1989, vol. 190 pp. 2041-2054, see p. 2047, and p. 2050.
Immunogen Inc.
Tate Christopher R.
Ward Edward
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