Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2011-01-11
2011-01-11
Kishore, Gollamudi S (Department: 1612)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
Reexamination Certificate
active
07867512
ABSTRACT:
The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.
REFERENCES:
patent: 5256422 (1993-10-01), Albert et al.
Merriam-Webster dictionary, 2001, p. 371.
Alberts et al ,Molecular Biology of the Cell, 3rd ed., pp. 489-493; pp. 800-801, Garland Publishing, Inc., New York (1994).
Angelova et al., “Preparation of giant vesicles by external AC electric fields.Kinetics and applications”;Prog. Coll. Polym. Sci.89:127 (1992).
Bates, “Polymer-Polymer Phase Behavior”,Science251:898 (1991).
Bloom et al., “Physical properties of the fluid lipid-bilayer component of cell membranes: a perspective”,Q. Rev. Biophys.24 (3):293 (1991).
Chaieb et al. “Spontaneous curvature-induced pearling instability”,Phys. Rev. E58:7733 (1998).
Cevc & Lasic inHandbook of Biological Physics, Chaps. 9-10, (1995).
Cornelissen et al., “Helical Superstructures from Charged Poly(styrene)-Poly(isocyanodipeptide) Block Copolymers”,Science280:1427 (1998).
Ding and Lieu, “Water-Soluble Hollow Nanospheres as Potential Drug Carriers”,J. Phys. Chem. B102:6107-6113 (1998).
Discher et al., “Polymersomes: Tough Vesicles Made from Diblock copolymers”,Science284:1143 (May 14, 1999).
Dobereiner et al , “Mapping vesicle shapes into the phase diagram: A comparison of experiment and theory”,Phys. Rev. E55:4458 (1997).
Deuling et al., “The Curvature Elasticity of Fluid Membranes: A Catalogue of Vesicle Shapes”,J. Phys.37:1335 (1976).
Evans and Needham, “Physical Properties of Surfactant Bilayer Membranes: Thermal Transitions, Elasticity, Rigidity, Cohesion, and Colloidal Interactions”,J. Phys. Chem.91, 4219 (1987).
Evans et al., “Entropy-Driven Tension and Bending Elasticity in Condensed-fluid Membranes”,Phys. Rev. Lett.64 (17): 2094 (1990).
Fendler et al., “Polymerized Surfactant Vesicles: Novel Membrane Mimetic Systems”,Science223:888 (1984).
Harasym et al., “Intratumor distribution of doxorubicin following i.v. administration of drug encapsulated in egg phosphatidylcholine/cholesterol liposomes”,Cancer Chemother. Pharmacol.40:309 (1997).
Hajduk et al., “Complex Phase Behavior in Aqueous Solutions of Poly(ethylene oxide)-Poly(ethylethylene) Block Copolymers”,J. Phys. Chem. B102:4269 (1998).
Helfrich et al, “Undulations, Steric Interactions and Cohesion of Fluid Membranes”,Il Nuovo Cimento 3D:137 (1984).
Henselwood et al., “Water-Soluble Porous Nanospheres”,Macromolecules31:4213 (1998).
Hentze et al, “Lyotropic Mesophases of Poly(ethylene oxide)-b-poly(butadiene) Diblock Copolymers and Their Cross-Linking To Generate Ordered Gels”,Macromolecules32 (18): 5803-5809 (Jul. 30, 1999).
Hillmyer and Bates, “Synthesis and Characterization of Model Polyalkane-Poly(ethylene oxide) Block Copolymers”,Macromolecules29: 6994 (1996).
Hillmyer et al., “Complex Phase Behavior in Solvent-Free Nonionic Surfactants”,Science271:976-978 (1996).
J. Israelachvili, “Fluid-Like Structures and Self-Assembling Systems: Micelles, Bilayers and Biological membranes”, Part 3, 2nded.,Intermolecular and Surface Forces(1995).
Koltover et al., An Inverted Hexagonal Phase of Cationic Liposome-DNA Complexes Related to DNA Release and Delivery,Science281:78 (1998).
Komatsu et al., “Solid Vesicle Membrane Made of”meso-Tetrakis[(bixinylamino)-o-phenyl]porphyrins,J. Am. Chem. Soc.119:11660 (1997).
Lin et al., “Cryogenic Electron Microscopy of Rodlike or Wormlike Micelles in Aqueous Solutions of Nonionic Surfactant Hexaethylene Glycol Monohexadecyl Ether”,Langmui, 8: 2200 (1992).
Lipowsky and Sackmann, Eds., “Structure and Dynamics of Membranes from Cells to Vesicles”,Handbook of Biological Physics, vol. 1, Chap. 1-4, 5-10 (Elsevier Science, Amsterdam, 1995).
Liu and O'Brien, “Cross-Linking Polymerization in Two-Dimensional Assemblies: Effect of the Reactive Group Site”,Macromolecules32:5519-5524 (Aug. 7, 1999).
Longo et al., “Interaction of the Influenza Hemagglutinin Fusion Peptide with Lipid Bilayers: Area Expansion and Permeation”,Biophys. J.73:1430 (1997).
Mueller et al., “Light-Stimulated Destabilization of PEG-Liposomes”,Polymer Preprints(ACS) 40(2): 205-206 (Aug. 22, 1999).
Needham et al., “The Mechanochemistry of Lipid Vesicles Examined by Micropipet Manipulation Techniques”, inVesicles, M. Rosoff, Ed. (Dekker, New York), Chap. 9 (1996).
Needham et al., “Elastic deformation and failure of lipid bilayer membranes containing cholesterol”,Biophys. J.58:997 (1990).
Netz et al., “Pore formation and rupture in fluid bilayers”,Phys. Rev. E53 (4): 3875 (1996).
Petrov, A.G. and Bivas, I., “Elastic and Flexoelectic Aspects of Out-of-Plant Fluctuations in biological and Model Membranes”,Prog. Surf. Sci.18:359 (1984).
Schmid-Schoenbein et al., “Spectrin, Red Cell Shape and Deformability”,Blut52(3):131 (Springer-Verlag 1986).
Seifert et al., “Shape transformations of vesicles: Phase diagram for spontaneous-curvature and bilayer-coupling models”,Phys. Rev. A44:1182 (1991).
Sisson et al., “Cross-Linking Polymerizations in Two-Dimensional Assemblies”,Macromolecules29:8321 (1996).
Svetina et al., “Membrane bending energy and shape determination of phospholipid vesicles and red blood cells”,Eur. Biophys J,.17:101 (Springer-Verlag 1989).
Szleifer et al., “Curvature Elasticity of Pure and Mixed Surfactant Films”,Phys. Rev. Lett.60(19): 1966 (1988).
Stefely et al, “Permeability Characteristics of Lipid Bilayers from Lipoic Acid Derived Phosphatidylcholines: Comparison of Monomeric, Cross-Linked and Non-Cross-Lined Polymerized Membranes”,J. Am. Chem. Soc.110:7463-7469 (1988).
Uchegbu et al., “Polymeric Chitosan-based Vesicles for Drug Delivery”,J. Pharm. Pharmacol.50:453 (1998).
Warriner et al., “Lamellar Biogels: fluid-Membrane-Based Hydrogels Containing Polymer Lipids”,Science271: 969 (1996).
Won et al., “Giant Wormlike Rubber Micelles”,Science283:960-3 (Feb. 12, 1999).
Yu et al., “Morphogenic Effect of Solvent on Crew-Cut Aggregates of Amphiphilic Diblock Copolymers”,Macromolecules31:1144 (1998).
Bates Frank
Discher Bohdana M.
Discher Dennis E.
Hammer Daniel A.
Lee James C-M
Kishore Gollamudi S
Regents of the University of Minnesota
Riverside Law LLP
The Trustees of the University of Pennsylvania
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