Cross-linked microparticles and their use as therapeutic vehicle

Details Cross-linked microparticles and their use as therapeutic vehicle Cross-linked microparticles and their use as therapeutic vehicle

1997-06-16

1999-09-21

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424423, 424426, 424490, 514937, 514952, A61K 914, A61K 950

Patent

active

059551089

ABSTRACT:
A sterile powder comprising microparticles, 0.1 to 50 .mu.m in diameter, obtainable by spray-drying and cross-linking a water-soluble material having free functional groups, is characterized in that the microparticles are hydrophilic, can be reconstituted in water to give a monodisperse suspension, and have retained said groups available for derivatization. The particles are linked to drugs or other functional molecules, and used as vehicles in therapy.

REFERENCES:
patent: 3565559 (1971-02-01), Sato et al.
patent: 3960583 (1976-06-01), Netting et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5663198 (1997-09-01), Reul et al.

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