Cross-linked heparin coatings and methods

Details Cross-linked heparin coatings and methods Cross-linked heparin coatings and methods

2003-12-10

2008-12-23

Kwon, Brian-Yong S (Department: 1614)

Stock material or miscellaneous articles

Composite

Of silicon containing

C427S448000, C427S002100, C424S423000, C424S447000, C424S445000, C514S056000, C536S021000

Reexamination Certificate

active

07468210

ABSTRACT:
A thromboresistant coating for a medical device, method of coating and coated medical device, the coating including an in situ cross-linked co-polymer of a cross-linkable biomolecule, preferably an adsorbable biomolecule such as a heparin activity biomolecule with at least one prosthetic hydrophobic unit, and a multifunctional crosslinking agent, such as a bis-variant of polyethylene glycol, polyethylene oxide, or polyethylene glycol, wherein the crosslinking is by means of covalent complexation through at least two functional groups of the multifunctional crosslinking agent.

REFERENCES:
patent: 3272204 (1966-09-01), Artandi et al.
patent: 4193138 (1980-03-01), Okita
patent: 4747848 (1988-05-01), Maini
patent: 4842575 (1989-06-01), Hoffman, Jr. et al.
patent: 5197977 (1993-03-01), Hoffman, Jr. et al.
patent: 5509899 (1996-04-01), Fan et al.
patent: 5510418 (1996-04-01), Rhee et al.
patent: 5650234 (1997-07-01), Dolence et al.
patent: 5665114 (1997-09-01), Weadock et al.
patent: 5916585 (1999-06-01), Cook et al.
patent: 5945457 (1999-08-01), Plate et al.
patent: 5955588 (1999-09-01), Tsang et al.
patent: 6051648 (2000-04-01), Rhee et al.
patent: 6096798 (2000-08-01), Luthra et al.
patent: 6099562 (2000-08-01), Ding et al.
patent: 6120904 (2000-09-01), Hostettler et al.
patent: 6231600 (2001-05-01), Zhong
patent: 6231892 (2001-05-01), Hubbell et al.
patent: 6248057 (2001-06-01), Mavity et al.
patent: 6258371 (2001-07-01), Koulik et al.
patent: 6270788 (2001-08-01), Koulik et al.
patent: 6306165 (2001-10-01), Patnaik et al.
patent: 6309660 (2001-10-01), Hsu et al.
patent: 6342591 (2002-01-01), Zamora et al.
patent: 6368347 (2002-04-01), Maini et al.
patent: 6387978 (2002-05-01), Ronan et al.
patent: 6406687 (2002-06-01), Luthra et al.
patent: 6410044 (2002-06-01), Chudzik et al.
patent: 6458889 (2002-10-01), Trollsas et al.
patent: 6491965 (2002-12-01), Berry et al.
patent: 6497729 (2002-12-01), Moussy et al.
patent: 6514534 (2003-02-01), Sawhney
patent: 6534591 (2003-03-01), Rhee et al.
patent: 6585765 (2003-07-01), Hossainy et al.
patent: 6596699 (2003-07-01), Zamora et al.
patent: 6630580 (2003-10-01), Tsang et al.
patent: 6818018 (2004-11-01), Sawhney
patent: 6921811 (2005-07-01), Zamora et al.
patent: 6984393 (2006-01-01), Amsden
patent: 7025990 (2006-04-01), Sawhney
patent: 7241736 (2007-07-01), Hunter et al.
patent: 2002/0115836 (2002-08-01), Tsang et al.
patent: 2002/0160098 (2002-10-01), Zamora et al.
Zamora, Paul O.; Tsang, Ray; Pena, Louis A.; Osaki, Shigemasa; and Som, Prantika, “Local Delivery of Basic Fibroblast Growth Factor (bFGF) Using Adsorbed Silyl-heparin, Benzyl-bis (dimethylsilylmethyl)oxycarbamoyl-heparin,” Bioconjugate Chem. 2002, 13, 920-926.
James Laredo, M.D., Ph.D., Lian Xue, M.D., Ph.D., Vicki A. Husak, Joan Ellinger, Howeard P. Greisler, M.D., “Silyl-heparin adsorption improves the in vivo thromboresistance of carbon-coated polytetrafluoropethylene vascular grafts,” The America Journal of Surgery 186 (2003) 556-560.

Affiliated with

Also associated with

Rating

Cross-linked heparin coatings and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cross-linked heparin coatings and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cross-linked heparin coatings and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4041487