Cross-linked glycopeptide-cephalosporin antibiotics

Details Cross-linked glycopeptide-cephalosporin antibiotics Cross-linked glycopeptide-cephalosporin antibiotics

2008-06-19

2011-12-27

Bradley, Christina (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

08084417

ABSTRACT:
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

REFERENCES:
patent: 4220761 (1980-09-01), Takaya et al.
patent: 4341775 (1982-07-01), Takaya et al.
patent: 4366153 (1982-12-01), Takaya et al.
patent: 4487767 (1984-12-01), Takaya et al.
patent: 4921851 (1990-05-01), Kishimoto et al.
patent: 4943567 (1990-07-01), Nishizawa et al.
patent: 5693791 (1997-12-01), Truett et al.
patent: 6392012 (2002-05-01), Judice et al.
patent: 6437119 (2002-08-01), Truett et al.
patent: 6635618 (2003-10-01), Leadbetter et al.
patent: 6878686 (2005-04-01), Marquess et al.
patent: 6974797 (2005-12-01), Fatheree et al.
patent: 7067481 (2006-06-01), Fatheree et al.
patent: 7067482 (2006-06-01), Fatheree et al.
patent: 7127856 (2006-10-01), Hagen et al.
patent: 7279458 (2007-10-01), Fatheree et al.
patent: 2003/0008812 (2003-01-01), Christensen et al.
patent: 2005/0049193 (2005-03-01), Grasso et al.
patent: 2033377 (1980-05-01), None
patent: 60-41682 (1985-03-01), None
patent: 99/42476 (1999-08-01), None
patent: 99/64049 (1999-12-01), None
patent: 00/39156 (2000-07-01), None
patent: 03/031449 (2003-04-01), None
Boeckh et al., “Pharmacokinetics and Serum Bactericidal Activity of Vancomycin Alone and in Combination with Ceftazidime in Healthy Volunteers”, Antibacterial Agents and Chemotherapy, vol. 32, No. 1, pp. 92-95 (1988).
Hammes, W. P., “Biosynthesis of Peptidoglycan in Gaffkya homari. The Mode of Action of Penicillin G and Mecillinam”, Eur. J. Biochem., vol. 70, pp. 107-113 (1976).
Kim et al., “Synthesis and Antibacterial Activity of Cephalosporins Having Hydroxamic Acid at C-7 Position”, Biorganic & Med. Chem. Letters, vol. 6, No. 17, pp. 2077-2080 (1996).
Lattrell et al., “Synthesis and Structure-Activity Relationships in the Cefpirome Series”, Journal of Antibiotics, vol. XLI, No. 10, pp. 1374-1394 (1988).
Pavlov, et al., “A New Type of Chemical Modification of Glycopeptides Antibiotics: Aminomethylated Derivatives of Eremomycin and Their Antibacterial Activity”, The Journal of Antibiotics, 50(6), pp. 509-513 (1997).
Pavlov et al., “Chemical Modification of Glycopeptide Antibiotics [VC1]”, Russian Journal of Bioorganiz Chemistry, vol. 24, No. 9, pp. 570-587 (1998).
Rao et al., “Tight Binding of a Dimeric Derivative of Vancomycin with Dimeric L-Lys-D-Ala-D-Ala”, J. Am. Chem. Soc., vol. 119, pp. 10286-10290 (1997).
Renoud-Grappin et al., “Imidazo[1,5-b]pyridazine-d4T conjugates:synthesis and anti-human immunodeficiency virus evaluation”, Antiviral Chemistry & Chemotherapy, vol. 9, pp. 205-223, (1998).
Staroske et al., “Synthesis of Covalent Head-to-Tail Dimers of Vancomycin”, Tetrahedron Letters, vol. 39, pp. 4917-4920 (1998).
Sundram et al., “General and Efficient Method for the Solution- and Solid-Phase Synthesis of Vancomycin Carboxamide Derivatives”, J. Org. Chem., vol. 60, pp. 1102-1103 (1995).
Sundram et al., “Novel Vancomycin Dimers with Activity against Vancoymcin-Resistant Enterococci”, J. Am.Chem. Soc., vol. 118, pp. 13107-13108 (1996).
JP 60-41682 (English Abstract), (1985).
U.S. Appl. No. 09/457,926, filed Dec. 8, 1999.
International Search Report for PCT/US03/16375, Aug. 28, 2003.

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