Cross-linked alginate transdermal medicine delivery devices

Details Cross-linked alginate transdermal medicine delivery devices Cross-linked alginate transdermal medicine delivery devices

1994-12-29

1996-01-16

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424484, 424445, 514343, 514813, A61K 970, A61K 31465

Patent

active

054846048

ABSTRACT:
A process for preparing a transdermal drug delivery device includes preparing a polymer matrix by homogenizing about 7 weight % sodium alginate with about 3.5 weight % glycerol for about 5 minutes, mixing with about 0.5 weight % nicotine in about 89 weight % distilled water, casting the mixture over a backing material and drying overnight, and spraying with an about 5 weight % solution of calcium ions to cross-link. A control release membrane is prepared by homogenizing about 3.1 weight % of sodium alginate with about 3.6 weight % of glycerol for about 5 minutes, mixing with about 93.3 weight % of distilled water, casting the mixture over a backing material and drying overnight, and spraying with an about 5 weight % solution of calcium ions to cross-link. And, the drug delivery device is assembled by cutting a circle of the polymer matrix and a circle of the control release membrane and assembling them in sequence on a piece of backing material.

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Budavari, S. (1989), The Merck Index. (Eleventh edition). Merck & Co., Inc. pp. 41-42.
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Hensyl, W. R. (1990). Stedman's Medical Dictionary (25th edition). Williams and Wilkins Publishers, pp. 33 and 43.

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