Cripto tumour polypeptide

Details Cripto tumour polypeptide Cripto tumour polypeptide

2001-08-20

2008-10-21

Yu, Misook (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Reexamination Certificate

active

07439320

ABSTRACT:
Compositions and methods for the therapy and diagnosis of cancer, particularly lung, colon, colorectal and breast cancer, are disclosed. Illustrative compositions comprise one or more Cripto tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung, colon, colorectal and breast cancer.

REFERENCES:
patent: 5256643 (1993-10-01), Persico et al.
patent: 5633147 (1997-05-01), Meissner et al.
patent: 5854399 (1998-12-01), Salomon et al.
patent: 6270777 (2001-08-01), Sokol et al.
patent: WO 00/06723 (2000-02-01), None
patent: WO 01/94629 (2001-12-01), None
patent: WO 02/077033 (2002-10-01), None
Sloane et al (Journal of Biotechnology, 1996, 49:231-238).
Lederman et al (Molecular Immunology 28:1171-1181).
Sloane (Journal of Biological Chemistry, 1996, 49:231-238).
Baldassarre et al., Transfection with a Cripto anti-Sense Plasmid Suppresses Endogenous Cripto Expression and Inhibits Transformation in a Human Embronal Carcinoma Cell Line, Int. J. Cancer 4(66):538-543 (1996).
Brandt et al., Indentification and biological Characterization of an Epidermal Growth Factor-Related Protein: Cripto-1, J. of Biological Chemistry 269(25):17320-17328 (1994).
Ciardiello et al., Differental Expression of Epidermal Growth Factor-Related Proteins in Human Colorectal Tumors, Proc. Natl. Acad. Sci. USA 88:7792-7796 (1991).
Ciardiello et al., Inhibition of CRIPTO Expression and Tumorigenicity in Human Colon Cancer Cells by Antisense RNA and Oligodeoxynucleotides, Onocgene 9:291-298 (1994).
Fontanini et al., Evaluation of Epidermal Growth Factor-related Growth Factors and Receptors and of Neoangiogenesis in Completely Resected Stage I-ILA Non-Small-Cell Lung Cancer: Amphiregulin and Microvessel Count are Independent Prognostic Indicators of Survival, Clinical Cancer Research 4:241-249 (1998).
Normanno et al., Growth Inhibition of Human Colon Carcinoma Cells by Combinations of Anti-Epidermal Growth Factor-related Growth Factor Antisense Olignoucleotides, Clinical Cancer Research 2:601-609 (1996).
Panico et al., Differential Immunohistochemical Detection of Transforming Growth Factor α, Amphiregulin and Cripto in Human Normal and Malignant Breast Tissues, Int. J. Cancer 65:51-56 (1996).
Saiki et al., Differential Immunohistochemical Detection of Amphiregulin and Cripto in Human Normal colon and Colorectal Tumors, Cancer Research 52:3467-3473 (1992).
Seno et al., Purification and Characterization of a Recombinant Human Cripto-1 Protein, Growth Factors 15:215-229.
PCT International Search Report.

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