CRF binding protein antibodies and assays using same

Details CRF binding protein antibodies and assays using same CRF binding protein antibodies and assays using same

1995-06-07

1998-03-31

Wolski, Susan

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435 78, 435 792, 435 793, 435 794, 436501, 436540, 436548, 436811, 436817, 5303871, 5303881, 53038824, 5303891, 5303892, 5303911, 5303913, G01N 33543

Patent

active

057337900

ABSTRACT:
Corticotropin Releasing Factor-binding protein (CRF-BP) is produced recombinantly and is useful for modulating the biological activity of CRF. CRF-BP or fragments thereof and/or antibodies to such polypeptides are employed in diagnostic assays to determine the levels of CRF and CRF-BP and the ratio of CRF/CRF-BP in a vascular fluid sample. Following such an assay, pregnancy-related pathological disorders, such as increased risk of premature labor, can be treated, for example, by administering CRF-BP to lower the ratio of CRF/CRF-BP to within a normal range for pregnancy. Anti-CRF-BP antibodies are also useful to purify CRF-BP and to modulate the biological effect of CRF-BPs.

REFERENCES:
Linton et al., "Carticotripin-Releasing Hormone (CRH)-Binding Protein: Reduction in the Adrenocorticotripin-Releasing Activity of Placental but no Hypothalamic CRH," Journal of Clinical Endocrinology and Metabolism, vol. 70, No. 6, pp. 1574-1580, (1990).
Linton et al., "Purified CRF Binding Protein Reduces at ACTH-Releasing Activity of CRF," Journal of Endocrinology, vol. 121, supplement, abstract 194, (Apr. 1989).
Potter et al., "The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF", Proceedings of the National Academy of Sciences, vol. 89, pp. 4192-4196, (1992).
Linton et al., "Comparison of a specific two-site immunoradiometric assay with radioimmunoassay for rat/human CRF-41," Regulatory Peptides, vol. 14, No. 1, pp. 69-84, (1986).
Linton et al., "Corticotropin Releasing Hormone-Binding Protein (CRH-BP): Plasma Levels Decrease During the Third Trimester of Normal Human Pregnancy," Journal of Clinical Endocrinology and Metabolism, vol. 76, No. 1, pp. 260-262, (1993).

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