Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1995-07-31
1998-06-16
Chambers, Jasemine C.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
4351723, 435 691, 4353201, 424 921, C12N 500, C12N 1500, C12N 1509, C12N 1563
Patent
active
057673373
ABSTRACT:
A transgenic mouse that expresses the human Apo E isoforms Apo E2, Apo E3 or Apo E4 but is essentially incapable of expressing endogenous Apo E. Additionally, mice that express more than one of these isoforms are produced by selectively breeding the transgenic mice expressing the different Apo E isoforms disclosed herein. Thus, the present invention allows, among other things, the study of the effects of different combinations of human Apo E isoform expression on normal brain biology, development, function, aging and injury.
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Gilbert John R.
Roses Allen D.
Schmechel Donald E.
Xu Pu-Ting
Chambers Jasemine C.
Duke University
Schmuck Jill D.
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