Creatinine biosensor

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S024000, C435S175000, C435S176000, C435S817000

Reexamination Certificate

active

06861232

ABSTRACT:
The present invention generally relates to a method for producing biosensors and a biosensor for determination of creatinine. The biosensor comprises at least two enzymes, for the amperometric determination of enzymatically degradable substances in biological liquids, the enzymes being immobilized on a working electrode.

REFERENCES:
patent: 5466575 (1995-11-01), Cozzette et al.
patent: 6241863 (2001-06-01), Monbouquette
patent: 2682765 (1993-04-01), None
Sirkir et al. “Glucose and Lactate Biosensors Based on Redox Polymer/Oxidoreductase Nanocomposite Thin Films,” Anal. Chem. (2000) 72(13): 2930-2936.*
Armstrong et al. “Recent Developments in Faradaic Bioelectrochemistry,” Electrochimica Acta (2000) 45:2623-2645.*
Okahata et al. “Preparations of Langmuir-Blodgett Films Enzyme-Lipid Complexes: A Glucose Sensor Membrane,” Thin Solid Films (1989) 180: 65-72.*
Surareugchai et al. “Dual Electrode signal-subtracted biosensor for simultaneous flow injection determination of surcrose and glucose,” Anal. Chimica Acta (1999) 380(1): 7-15.*
Tsuchida, Toshio et al., “Multi-Enzyme Membrane Electrodes for Determination of Creatinine and Creatine in Serum” Clinical Chemistry, vol. 29, No. 1 1983 (pp. 51-55).

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