Creatinine antibody

Details Creatinine antibody Creatinine antibody

1984-10-02

1986-03-25

Schain, Howard E.

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

260112B, 260112R, 424 85, G01N 3354, A61K 3900, C07G 700

Patent

active

045783616

ABSTRACT:
The present invention provides a creatinine antibody and a process for the preparation thereof, wherein a conjugate of creatinine and a material suitable for antiserum formation, which are connected via an aliphatic or araliphatic carboxylic acid as bridge member, is used as immunogen for antiserum formation.
The present invention is also concerned with the use of the above antibody for the immunological determination of creatinine, wherein the antibody is incubated with a creatinine-containing sample solution, reacted with a conjugate of creatinine with a hapten carrier substance, whereby one of the components, antibody and conjugate, is present in the solid phase or in dissolved form and the other component is present in dissolved form and the inhibition of the binding reaction between the antibody and the creatinine conjugate is measured.
Furthermore, the present invention provides a reagent for the immunological determination of creatinine, wherein it contains the above antibody, a conjugate of creatinine with a hapten carrier substance and buffer substance.

REFERENCES:
patent: 4237044 (1980-12-01), Wurzburg et al.
patent: 4485177 (1984-11-01), Siedel et al.
Chem. Abstracts, vol. 93, 200497z, 1980.
Chem. Abstracts, vol. 92, 124433n, 1980.

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