Creating designer antimicrobials; peptidoglycan hydrolase...

Details Creating designer antimicrobials; peptidoglycan hydrolase... Creating designer antimicrobials; peptidoglycan hydrolase...

2011-07-19

2011-07-19

Noakes, Suzanne M (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S183000, C435S195000, C435S212000, C435S220000, C424S094100

Reexamination Certificate

active

07982003

ABSTRACT:
The invention concerns a nucleic acid encoding a recombinant bifunctional fusion peptidoglycan hydrolase protein formed from a nucleic acid encoding a peptidoglycan hydrolase module and a nucleic acid encoding a second peptidoglycan hydrolase module. The fusion, dual (or multiples thereof) peptidoglycan hydrolase modules can be used to treat disease caused by the bacteria for which the individual modules of the fusion protein are specific.

REFERENCES:
patent: 2010/0158886 (2010-06-01), Donovan et al.
Branden et al., “Introduction to Protein Structure Second Edition”, Garland Publishing Inc., New York, 1999.
Witkowski et al., Biochemistry, 38, 11643-11650, 1999.
Wishart et al., Journal of Biological Chemistry, vol. 270, No. 45, pp. 26782-26785, 1995.
Kisselev, Structure, vol. 10, pp: 8-9, 2002.
MESH search results for “peptidoglycan hydrolase”. Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh>.
MESH search results for “endolysin”. Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh>.

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