Creatine-fatty acids

Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...

Reexamination Certificate

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C554S103000, C554S105000, C554S227000, C562S887000

Reexamination Certificate

active

07314945

ABSTRACT:
The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

REFERENCES:
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patent: 03/099806 (2003-12-01), None
patent: 03/101402 (2003-12-01), None
patent: 2006/081682 (2006-08-01), None
Harris RC, et al. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). Sep. 1992;83(3):367-74.
Greenhaff PL, et al. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol. May 1994;266(5 Pt 1):E725-30.
Greenhaff PL, et al. Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci (Lond). May 1993;84(5):565-71.
Olsen S, et al. Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training. J Physiol. Jun. 2006;573(Pt 2):525-34.
Zammit PS, et al. The Skeletal Muscle Satellite Cell: The Stem Cell That Came In From the Cold. J Histochem Cytochem. Aug. 2006; 54(11):1177-91.
Sartorelli V, et al. Molecular and cellular determinants of skeletal muscle atropy and hypertropy. Sci STKE. Jul. 2004;(244):re11.
Willaims MH, et al. Creatine supplementation and exercise performance: an update. J Am Coll Nutr. Jun. 1998;17(3):216-34.
Dox AW, et al. Esterification of creatine. J Biol Chem. 1922;67:671-73.
PCT/CA2007/000257 International Search Report, International Filing Date: Feb. 20, 2007, Applicant: Multi Formulations Ltd. et al., date mailed: Jul. 18, 2007.

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