Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-10-25
1999-12-07
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514565, 514825, 514866, 514909, A61K 31415, A61K 31195
Patent
active
059984570
ABSTRACT:
The present invention relates to the use of creatine compounds for treating or preventing a metabolic disorder related to body weight control such as obesity, and it's associated diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group. (5) compounds which modify the association of creatine kinase with other cellular components.
REFERENCES:
patent: 5091404 (1992-02-01), Elgebaly
patent: 5321030 (1994-06-01), Kaddurah-Daouk et al.
patent: 5324731 (1994-06-01), Kaddurah-Daouk et al.
patent: 5627172 (1997-05-01), Almada et al.
Annesley, T.M. and J.B. Walker (1977) "Cyclocreatine Phosphate as a Substitute for Creatine Phosphate in Vertebrate Tissues. Energetic Considerations" Biochem. Biophys. Res. Commun. 74(1): 185-190.
Coleman, D.L. (1978) "Obese and Diabetes: Two Mutant Genes Causing Diabetes-Obesity Syndromes in Mice" Diabetologia 14: 141-148.
Cramer, F. et al. (1962) "Die Synthese der Argininphosphorsaure und die Reaktion von Isoureidophosphonaten mit Aminen" Chemische Berichte Jahrg. 95: 1670-1682.
Friedman, J.M. and R.L. Leibel (1990) "Tacking a Weighty Problem" Cell 69: 217-220.
Friedman, J.L. et al. (1991) "Molecular Mapping of the Mouse ob Mutation" Genomics 11: 1054-1062.
Griffiths, G.R. and J.B. Walker (1976) "Accumulation of Analog of Phosphocreatine in Muscle of Chicks Fed 1-Carboxymethyl-2-iminoimidazlidine (Cyclocreatine)" J. Biol. Chem. 251: 2049-2054.
Halaas, J.L. et al. (1995) "Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene" Science 269: 543-546.
Lowe. G. and B.S. Sproat (1980) "Evidence for an Associative Mechanism in the Phosphoryl Transfer Step Catalyzed by Rabbit Muscle Creatine Kinase" J. Biol. Chem. 225(9): 3944-3951.
McLaughlin, A.C. and M. Cohn (1972) "Specificity of Creatine Kinase for Guanidino Substrates" J. Biol. Chem. 247(13): 4382-4388.
Roberts, J.J. and J.B. Walker (1983) "Synthesis and Accumulation of an Extremely Stable High-Energy Phosphate Compound by Muscle, Heart, and Brain of Animals. . . " Arch. Biochem. Biophys. 220: 563-571.
Roberts, J.J. and J.B. Walker (1995) "Higher Homolog and N -Ethyl Analog of Creatine as Synthetic Phosphagen Precursors in Brain, Heart, and Muscle, Repressors of Liver Amidinotransferase, and Substrates for Creatine Catabolic Enzymes" J. Biol. Chem. 260: 13502-13508.
Rowley, G.L. et al. (1971) "On the Specificity of Creatine Kinase. New Glycocyamines and Glycocyamine Analogs Related to Creatine" J. Am. Chem. Soc. 93(21): 5542-5551.
Walliman, T. et al. (1992) "Intracellular compartmentation, stucture and function of creatine kinase isoenzymes in tissues with high and fluctating energy demands: the `phosphocreatine circuit` for cellular energy" Biochem. J. 281: 21-40.
Zhang, Y. et al. (1994) "Positional cloning of the mouse obese gene and its human homologue" Nature 372: 425-432.
Avicena Group, Inc.
Jordan Kimberly
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