Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Reexamination Certificate
1999-02-09
2001-07-17
Kulkosky, Peter F. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
C424S642000, C424S195110
Reexamination Certificate
active
06261574
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates, in general, to formulations utilized as topical applications to the skin for a variety of skin disorders and, more particularly, the present invention relates to a cream formulation which will exhibit enhanced soothing effects when utilized as a topical application to the skin for such variety of skin disorders and, still more specifically, this invention relates to a cream formulation which may provide temporary relief of minor pain.
BACKGROUND OF THE INVENTION
Prior to the conception and subsequent development of the present invention, as is generally well known in the prior art, there are a variety of skin creams and lotions today which are used to soften skin, repair lesions, combat dryness and redness, and reduce swelling and roughness in irritated skin. There are also a variety of creams or ointments that are used to reduce the itch from poison ivy and insect bites.
Virtually everyone has endured the discomfort of dry, chapped hands at one time or another or experienced rough, sore hands with cracks at every joint on the fingers. Not only hands but other external portions of the body are susceptible to dryness, irritation and lesions. Despite all of the products on the market, there is still a need for a topical product which will not only soften and moisturize dry and chapped hands but also provide healing for skin cracks and lesions.
In the area of topical creams and ointments there is a further need for a product which can be effective in the treatment of and prevention of cold sores caused by enveloped viruses such as the herpes simplex virus. Additionally, it would be useful to have a product that could be effective in treating shingles caused by herpes zoster and it's cousin chicken pox caused by herpes varicella. All three of these virus caused manifestations present unique problems in their treatment.
Another particular and agonizing problem is that of post-herpetic neuralgia (PHN). PHN is an ailment caused by having had herpes zoster. Up to 50% of elderly patients that have had shingles may develop PHN. As our life span increases and the number of elderly increase, correspondingly, the number of elderly who contract shingles increases also. An effective treatment for this disorder is thus becoming more and more important.
An important fact that must be understood with relation to PHN is that PHN is not a continuation of herpes zoster (shingles). It is a separate condition that is caused by having had shingles. There is evidence to suggest that PHN is not viral in nature, however, nothing conclusive has been established in this regard. PHN may be defined as pain that continues at the site of shingles beyond a period of 1-3 months. Incidence of PHN in young patients is rare, even up to 40 years of age.
However, in a study by the Pain Research Institute at the Walton Hospital, Liverpool, England, it was found that half of the patients who contracted shingles at age 60 developed PHN and the percentage increased to 75% for those diagnosed as having shingles at age 70 or older. As the average life span continues to increase and the number of elderly increases, the incidence is increasing at a very rapid rate.
Thus, there are many in the world that are eagerly waiting for a medication which could be used in the treatment of a variety of skin ailments, as well as for viral skin infections and the very painful and relatively untreatable post-herpetic neuralgia.
Use of a purified extract from the leaves of the plant
Eribotrya japonica
for the inhibition of the cytopathogenic effects of herpes simplex virus is described in U.S. Pat. No. 5,279,827. The method of preparation and purification of the extract is described in U.S. Pat. No. 5,137,722 and U.S. Pat. No. 5,279,827. The method of preparation and purification of the extract and the use of the purified extract for the inhibition of viruses described in these patents is incorporated herein by reference thereto.
SUMMARY OF THE INVENTION
In a first aspect of the present invention there is provided a cream formulation for topical application to an external portion of a human body. The active ingredients of a one ounce preparation of such cream formulation, in this embodiment, consists essentially of a predetermined weight of an aloe vera gel compound. Such predetermined weight of such aloe vera gel compound being present in the cream formulation generally in a range of between about 3 grams and about 10 grams. The cream formulation also includes a predetermined weight of a preselected zinc compound. Such predetermined weight of such zinc compound being present in the cream formulation generally in a range of between about 0.4 grams and about 1.5 grams. The active ingredients further contain a predetermined weight of a preselected vitamin E. Such predetermined weight of such preselected vitamin E being present in the cream formulation generally in a range (expressed as International Units) of between about 200 IU and about 9000 IU. The balance of such one ounce preparation of the cream formulation being made up of water, organic solvents, carriers and emollients.
In another embodiment of the invention the above described cream formulation further includes a purified extract of the leaves of the plant
Eriobotrya japonica.
OBJECTS OF THE INVENTION
It is, therefore, one of the primary objects of the present invention to provide a cream formulation for topical application which will generally be more effective as a treatment for dry, chapped, cracked and irritated skin than prior art type cream formulations.
It is also an object of the present invention to provide a cream formulation for topical application which will generally be more effective as a treatment for reducing the itch of poison ivy and insect bites than prior art type cream formulations presently being used for these afflictions.
It is still another object of the present invention to provide a cream formulation for topical application which in certain cases will be more effective as a treatment for the manifestation of herpes simplex, herpes zoster and herpes varicella than treatments presently being used.
Yet, it is another object of the present invention to provide a cream formulation for topical application which possesses the capability of being more effective as a treatment for post-herpetic neuralgia.
In addition to the number of objects and advantages of the present invention which have been discussed above, it should be noted that various other objects and advantages of the topical formulation for a variety of applications will become more readily apparent to those persons who are particularly skilled in the art from the following more detailed description of such invention.
REFERENCES:
patent: 4704280 (1987-11-01), Bates
patent: 5662937 (1997-09-01), McCuaig
patent: 5874094 (1999-02-01), Costello
patent: 5955083 (1999-09-01), Bonte et al.
Medline Abstract of China Patent No. 1080182, 1994.
James Ray & Associates
Kulkosky Peter F.
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