Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from vaccinium
Reexamination Certificate
2009-04-07
2011-10-11
Hoffman, Susan (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from vaccinium
C424S776000
Reexamination Certificate
active
08034389
ABSTRACT:
Isolated cranberry seed oil and components thereof, in a form suitable for use as a foodstuff, dietary supplement, or pharmaceutical composition, are disclosed. The isolated cranberry seed oil or compositions comprising one or a combination of components derived from the cranberry seed oil can be used as anticancer, hypocholesterolemic, antithrombotic, antioxidizing, antiatherogenic, antiinflammatory, and immunoregulatory agents. In addition, the invention features novel methods of extracting cranberry seed oil from cranberry seeds in a form suitable for adding to foodstuffs, dietary supplements, or pharmaceutical compositions.
REFERENCES:
patent: 4603142 (1986-07-01), Burger et al.
patent: 5188861 (1993-02-01), Mazin et al.
patent: 5320861 (1994-06-01), Mantius et al.
patent: 5419251 (1995-05-01), Mantius et al.
patent: 5525341 (1996-06-01), Walker et al.
patent: 5591772 (1997-01-01), Lane et al.
patent: 5646178 (1997-07-01), Walker et al.
patent: 5766571 (1998-06-01), Ceriani et al.
patent: 6261565 (2001-07-01), Empie et al.
patent: 6391345 (2002-05-01), Heeg et al.
patent: 6641847 (2003-11-01), Nawar
patent: 2002/0168430 (2002-11-01), Heeg et al.
patent: 0421419 (1991-04-01), None
patent: 0834261 (2003-10-01), None
patent: 98/30228 (1998-07-01), None
patent: 99/12541 (1999-03-01), None
patent: 99/15167 (1999-04-01), None
patent: 99/55350 (1999-11-01), None
https://health.google.com/health/ref/Familial+hypercholesterolemia—accessed Sep. 2010.
Bomser, J. et al, “In Vitro Anticancer Activity of Fruit Extracts from Vaccinium Species,” Planta Medica, vol. 62:212-216 (1996).
Borradaile et al., “Regulation of HepG2 cell Apolipoprotein B metabolism by the citrus flavanones hesperetin adn naringenin,” Lipids, vol. 34(6):591-8 (1999).
Camire, A.L. et al, “Effect of Cinnamic Acid on Anthocyanin Stability in Cranberry Juice,” Journal of Food Protection, vol. 43(1):36-37 (1980).
Carroll et al,. “Anticancer properties of flavonoids, with emphasis on citrus flavonoids,” In Flavonoids in health and disease; Rice-Evans (Eds.), Marcel Drekker, Inc., New York pp. 437-446 (1998).
Carroll et al., “Dietary fatty acids, tocotrienols and cancer,” Lipids, vol. 5:141-147 (1998).
Chen, Y., “Volatile components and oxidative stability of cranberry seed oil,” Thesis submitted to the Graduate School of the University of Massachusetts Amherst, Feb. 1997.
CNN.com, “High blood cholesterol,” retreived online at http://www.cnn.com/HEALTH/library/DS/00178.html, accessed 2006.
CNN.com, “Preventing cancer: 6 steps,” retreived online at http://www.cnn.com/HEALTH/library/CA/00024.html, accessed 2006.
Cook et al., “Flavonoids—chemistry, metabolism, cardioprotective effects and dietary sources,” J. Nutr. Biochem., vol. 7:66-76 (1996).
Croteau, Rodney and Fagerson, Irving S., “Seed Lipids of the American Cranberry,” Phytochemistry, vol. 8 (11):2219-22 (1969).
Fukuzawa et al., “Increased platelet-activating factor (PAF) synthesis in polymorphonuclear leukocytes of vitamin E-deficient rats,” Annals of the New York Academy of Sciences, vol. 570:449-453 (1989).
Guthrie et al., “Palm oil tocotrienols and plant flavonoids act synergistically with each other and with tamoxifen in inhibiting proliferation and growth of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells in culture,” J. Clin. Nutr. vol. 6(1):41-45 (1997).
Guthrie et al., “Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination,” J. Nutr. vol. 127(3):544S-548S (1997).
Guthrie et al., “Tocotrienols and cancer,” in: Biological Oxidants: Molecular Mechanisms and Health Effects, Packer and Augustine Eds., AOCS Press, Champaign, Illinois pp. 257-264 (1998).
Guthrie et al., “Inhibition of mammary cancer by citrus flavonoids,” In: Flavonoids in the living system, Manthey and Buslig Eds., Plenum Press, New York, pp. 227-236 (1998).
Guthrie et al., “Inhibition of human breast cancer cell growth and metastasis in nude mice by citrus juices and their constituent flavonoids,” In: Flavonoids in health and disease, Rice-Evans and Packer Eds., Marcel Dekker, Inc., New York, New York, pp. 310-316 (1998).
Heinonen, I. Marina et al., “Antioxidant of Berry and Fruit Wines and Liquors,” J. Agricultural & Food Chemistry, vol. 46(1):25-31 (1998).
Hertog et al., “Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands,” Nutr. Cancer, vol. 20:21-29 (1993).
Kamb, Alexander, “What's wrong with our cancer models?” Nature Reviews Drug Discovery, vol. 4:161-165 (2005).
Kates, Morris et al., “Isolation and Fractionation of Leaf Phosphatides,” Can. J. Botany, vol. 35(6):895-905 (1957).
Kurowska et al., “Role of tocotrienols from palm oil in regulation of Apo B metabolism in HepG2 cells,” FASEB, vol. 13(4):A562 (1999) (Abs.).
Manthey, John A. et al, “Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflammation,” Current Medicinal Chemistry, vol. 8:135-153 (2001).
Marwan, A.G. et al, “Indentification of the Hydroxycinnamtic Acid Derivatives in Cranberries,” Journal of Food Science, vol. 47:774-778 (1982).
Merck Index, Budaveri et al, eds. (1989). Merck and Co., Inc.: New Jersey, pp. 358, entry 2300.
Middeleton et al., “The flavonoids,” Trends Pharm. Sci., vol. 5:335-338 (1984).
Nesaretnam, Kalanithi et al, “Effect of Tocotrienols on the Growth of a Human Breast Cancer Cell Line in Culture,” Lipids, vol. 30(12):1139-1143 (1995).
Niki et al., “Inhibition of oxidation of biomembranes by tocopherol,” Annals of the New York Academy of Sciences, vol. 570:23-31 (1989).
Osborne et al., “Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer,” J. Natl. Cancer Inst., vol. 87:746-750 (1995).
Piironen, Vieno et al., “Tocopherols and Tocotrienols in Finnish Foods: Vegetables, Fruits, and Berries,” J. Agric. Food Chem., vol. 34:742-746 (1986).
Qureshi et al., “Suppression of cholesterogenesis by plant constituents: review of Wisconsin contributions to NC-167,” Lipids, vol. 20:817-24 (1985).
Qureshi et al., “The structure of an inhibitor of cholesterol biosynthesis isolated from barley,” J. Biol. Chem., vol. 261:10544-50 (1986).
Qureshi et al., “Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee),” Am. J. Clin. Nutr., vol. 53:1021S-6S (1991).
So et al., “Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices,” Nutr. Cancer, vol. 26:167-181 (1996).
So et al., “Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen,” Cancer Letters, vol. 112:127-133 (1997) and corrigendum.
Wang, Shiow Y. et al., “Ellagic Acid Content in Small Fruits, Mayhaws, and Other Plants,” J. Small Fruit & Viticulture, vol. 2(4):39-49 (1994).
Wilcox et al., “Naringenin, a citrus flavanoid, markedly decreases Apo B secretion in HepG2 cells and inhibits acyl CoA: cholesterol acyltransferase,” Circulation, vol. 98(17):1-537 (1998) (abs.).
Written Opinion for International Application No. PCT/US00/15309, dated Feb. 26, 2001.
International Preliminary Examination Report for International Application No. PCT/US00/15309, dated Feb. 26, 2001.
International Search Report for International Application No. PCT/US00/15309, dated Oct. 20, 2000.
Erickson Briana M.
Hoffman Susan
Nelson Mullins Riley & Scarborough LLP
Ocean Spray Cranberries Inc.
Remillard Jane E.
LandOfFree
Cranberry seed oil extract and compositions containing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cranberry seed oil extract and compositions containing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cranberry seed oil extract and compositions containing... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4273707