Crack prevention and improved thrombogenicity of implanted prost

Details Crack prevention and improved thrombogenicity of implanted prost Crack prevention and improved thrombogenicity of implanted prost

1987-06-18

1989-11-21

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424427, 523112, 604266, 623 1, 623 4, A61K 200

Patent

active

048821489

ABSTRACT:
Implantable devices for medical use are provided which have been subjected to treatment with a crack preventative/antithrombogenic agent in the form of a sulfate. This treatment substantially prevents surface cracking or fissuring of the subcutaneous implantation as well as preventing thrombus formation along the blood contacting surfaces of the treated material.

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patent: 4273873 (1981-06-01), Sugitachi et al.
patent: 4378435 (1983-03-01), Takagi et al.
patent: 4475972 (1984-10-01), Wong
patent: 4539373 (1985-09-01), Mani et al.
Pande, "Thermoplastic Polyurethanes as Insulating Materials for Long-Life Cardiac Pacing Leads", PACE, vol. 6, Sep.-Oct. 1983, Part I, pp. 858-867.
Goldberg et al, "Biocompatibility of Intraocular Lens Polymers", Apr. 1985.
Sulfonation and Related Reactions, Chapter 2, pp. 75-77.
Josefowicz et al, "Heparin-Like Biomaterials", Second World Congress on Biomaterials, 1984.

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