CpG single strand deoxynucleotides for use as adjuvant

Details CpG single strand deoxynucleotides for use as adjuvant CpG single strand deoxynucleotides for use as adjuvant

2008-12-05

2010-06-29

Mondesi, Robert B (Department: 1645)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

07745598

ABSTRACT:
The present invention provides an adjuvant, which includes at least one single strand deoxynucleotide containing a CpG dinucleotide. The single strand deoxynucleotide comprises one or more CpG dinucleotides. When used in combination with rabies vaccine, HBV vaccine or other vaccines, the adjuvant can significantly improve the immune effect of the vaccine.

REFERENCES:
patent: 6406705 (2002-06-01), Davis et al.
patent: 1498895 (2004-05-01), None
patent: 1526718 (2004-09-01), None
patent: 1526719 (2004-09-01), None
patent: WO 00/67023 (2000-11-01), None
Dreesen, D.W. (1997) “A Global Review of Rabies Vaccines for Human Use”,Vaccine15:S2-S6.
Yan J. et al. (1998) “Establishment of Rapid Fluorescence Focus Inhibition Test (RFFIT) for Detecting Neutralizing Antibody to Rabies Virus”, Tsinghua Tongfang Optical Disc Co., Ltd.

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