Coxsackie virus as a vector for delivery of anti-inflammatory cy

Chemistry: molecular biology and microbiology – Vector – per se

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536 235, 536 2351, 536 2352, C12N 1586

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active

060717424

ABSTRACT:
The present invention is drawn to the use of artificially attenuated Coxsackievirus B3 cardiotropic virus vectors as efficient gene transfer vectors to deliver immunomodulatory proteins and/or antigenic epitopes in transient infections to aid in preventing, ameliorating, and/or ablating infectious viral heart disease and reducing, or ablating entirely, heart transplant rejection. Additionally, other organs or tissues may be targeted with specific picornaviruses. An attenuated CVB3 viral vector able to express a cytokine is provided. This cytokine-expressing viral vector is able to deliver the cytokine to a target tissue and reduce disease symptoms

REFERENCES:
Verma et al., Nature, vol. 389, pp. 239-242, Sep. 18, 1997.
Leslie et al., Clinical Microbiology Reviews, vol. 2, No. 2, Apr. 1989, pp. 191-203.
M.B.A. Oldstone, Virology, vol. 234, 1997, pp. 179-185.
Cohen, Science, vol. 265, Sep. 2, 1994, pp. 1371-1373.
Zhang et al., American Journal of Pathology, vol. 150, No. 6, Jun. 1997, pp. 2197-2207.
Orkin et al., "Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy", Dec. 7, 1995.

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