Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2006-11-28
2006-11-28
Achutamurthy, P. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S004000, C435S440000, C435S018000, C435S025000, C435S252300, C435S320100, C435S069100, C435S071100, C530S350000, C536S023200, C514S789000
Reexamination Certificate
active
07141401
ABSTRACT:
Protein complexes are provided comprising COX1 and one or more proteins selected from the group consisting of THR S14 and Opa1. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treating and/or preventing diseases and disorders associated with COX1 and its interacting partner proteins. In addition, methods of detecting the protein complexes and modulating the functions and activities of the protein complexes or interacting members thereof are also provided.
REFERENCES:
Kinlaw, William B., et al., “Direct Evidence for a Role of the “Spot 14” Protein in the Regulation of Lipid Synthesis”,The Journal of Biological Chemistry, Jul. 14, 1995; 270(28):16615-16618.
Cunningham, Barbara A., et al., “Spot 14 Protein—Protein Interactions: Evidence for Both Homo- and Heterodimer Formationin vivo”, Endocrinology, 1997; 138(12):5184-5188.
Tang, Dean G., “Suppression of W256 Carcinosarcoma Cell Apoptosis by Arachidonic Acid and Other Polyunsaturated Fatty Acids”,Int. J. Cancer, 1997; 72:1078-1087.
Brown, Suzanne B., et al., “Spot 14 ” Protein functions at the Pretranslational Level in the Regulation of Hepatic Metabolism by Thyroid Hormone and Glucose,The Journal of Biological Chemistry, Jan. 24, 1997; 272(4):2163-2166.
Cunningham, Barbara A., et al., “Spot 14 Protein: A Metabolic Integrator in Normal and Neoplastic Cells”,Thyroid, 1998; 8(9):815-825.
Hla, Timothy, et al., “Cyclooxygenase-1 and -2 isoenzymes”The International Journal of Biochemistry&Cell Biology, 1999.
Langenbach, Robert, et al., “Cyclooxygenase-deficient Mice: A Summary of Their Characteristics and Susceptibilities to Inflammation and Carcinogenesis”,Annals New York Academy of Sciences, 1999; 889:52-61.
Heemers, Hannelore, et al., “Progestins and Androgens Increase Expression of Spot 14 in T47-D Breast Tumor Cells”,Biochemical and Biophysical Research Communications, 2000; 269:209-212.
Dubois, R.N., “Review article: cyclooxygenase—a target for colon cancer prevention”,Aliment Pharmacol. Ther., 2000; 14(1):64-67.
Delettre, Cecile, et al., “Nuclear geneOPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy”,Nature Genetics, Oct. 2000; 26:207-210.
Alexander, Christiane, et al., “OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28”,Nature Genetics, Oct. 2000; 26:211-215.
Taviaux, S., et al., “Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5→q14.1 by in situ hybridization”Cytogenetics and Cell Genetics1997; 76:219-220.
Votruba, M., et al., “Genetic refinement of dominant optic atrophy (OPA1) locus to within a 2 cM interval of chromosome 3q”,J Med Genet., 1997; 34(2)117-121.
Mater, K., et al., “Arachidonic acid and PGE2regulation of hepatic lipogenic gene expression”,Journal of Lipid Research, 1999; 40:1045-1052.
Achutamurthy P.
Ley, III Herbert L
Myriad Genetics Inc.
Myriad Genetics IP Department
Pak Yong D.
LandOfFree
COX1-interacting proteins and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with COX1-interacting proteins and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and COX1-interacting proteins and use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3640831