Coversion of substituted 8-chloroquinolines to substituted 8-hyd

Details Coversion of substituted 8-chloroquinolines to substituted 8-hyd Coversion of substituted 8-chloroquinolines to substituted 8-hyd

1995-05-24

1997-01-28

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546180, C07D21518, C07D21526

Patent

active

055979246

ABSTRACT:
The invention is a process for preparing substituted 8-hydroxyquinolines from substituted 8-chloroquinolines.

REFERENCES:
patent: 4520099 (1985-05-01), Akimura
patent: 4609734 (1986-09-01), Quarroz
Thomas Brown, "Reversible Inhibitors of the Gastric . . . ", J. Med. Chem, vol. 33, pp. 527-533, 1990.
Gerard Leclerc, "Cardiotonic Agents . . . ", J. Med. Chem., vol. 29, pp. 2433-2438, 1986.
Woroshzow; Mizengendler, Ah. Obshch. Khim., 6(1936)63. Conversion of unsubstituted 8-chloroquinoline to 8-hydroxyquinoline with cuprous salts in aqueous sodium hydroxide at 250 deg C.
Kawasaki, Shinjiro; Hirano, Akio; Hayashi, Yasuo (Taoka Dyestuffs Manufg. Co., Ltd.) Japan Kokai 73 54078, 30 Jul. 1973, Chem Abstr. 80, 37019 (1974).
Onishi, Isao; Agatsuma, Shigeru; Yamada, Hiroyuki; Yasuse, Shuichi; Murase, Yoshio (Yuki Gosei Kogyo Co., Ltd.) Japan Patent 47037436, 20 Sep. 1972, Chem Abstr. 78, 16059x (1972).

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