Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1985-04-04
1987-09-22
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530402, 530403, 530404, 530405, 530406, 424 88, 424 92, 536 551, 536 11, 536123, 536 54, 435 7, 435188, C07K 1504, A61K 3702, A61K 3902
Patent
active
046956247
ABSTRACT:
Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides, proteins and conjugates and of confirming the covalency of the linkage between polysaccharides and proteins.
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Marburg et al., "Limitation of Cyonogen Bromide Activation of Polysaccharides", Merck Sharp and Dohme Res. Lab. publication.
Kniskern Peter J.
Marburg Stephen
Tolman Richard L.
Draper Garnette D.
Elder Richard A.
Kight John
Levitt Julian S.
Merck & Co. , Inc.
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