Covalently linked polypeptide cell modulators such as interferon

Details Covalently linked polypeptide cell modulators such as interferon Covalently linked polypeptide cell modulators such as interferon

1989-07-13

1992-05-19

Nucker, Christine

Drug, bio-affecting and body treating compositions

Lymphokine

424 852, 424 854, 424 855, 424 856, 424 857, 424 858, 530351, 530395, 530405, 530409, 5303911, 5303917, 5303919, 53038823, 5303892, 514 2, 514 8, 514 12, 514 21, 930142, 930143, A61K 3766, A61K 3944, C07K 1526, C07K 1702

Patent

active

051147114

ABSTRACT:
Described is a new class of polypeptide cell modulators characterized by being composed of two covalently linked cell modulators in a linear polypeptide sequence. Such dual function polypeptides have new and particularly useful activities when the component polypeptide cell modulators are interferons, lymphokines or cytotoxins which act through different and specific cell receptors to initiate complementary biological activities.

REFERENCES:
patent: Re32637 (1988-04-01), Ishida
patent: 4468382 (1984-08-01), Bacha et al.
Rudinger in J. A. Parsons ed Peptide Hormones Univ. Park Press Baltimore, Jun. 1976 pp. 1-7.
CA 106(9):159 abstract #62196j.
Shepard et al (1984) Nature 294:563-565.

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