Covalently linked polypeptide cell modulators

Drug – bio-affecting and body treating compositions – Lymphokine – Interferon

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424 856, 424 857, 530351, 435 6951, A61K 4502, C07K 1526, C07K 1300, C12P 2100

Patent

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049352334

ABSTRACT:
Described is a new class of polypeptide cell modulators characterized by being composed of two covalently linked cell modulators in a linear polypeptide sequence. Such dual function polypeptides have new and particularly useful activities when the component polypeptide cell modulators are interferons, lymphokines or cytotoxins which act through different and specific cell receptors to initiate complementary biological activities.

REFERENCES:
patent: 4468382 (1984-08-01), Bacha et al.
patent: 4691009 (1987-09-01), Palmer et al.
patent: 4734491 (1988-03-01), Caruther
patent: 4758428 (1988-07-01), Mark et al.
Shepard et al., Nature, vol. 294, pp. 563-565, 1981.

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