Covalently linked oligonucleotide minor grove binder conjugates

Details Covalently linked oligonucleotide minor grove binder conjugates Covalently linked oligonucleotide minor grove binder conjugates

1998-08-27

2000-07-04

Riley, Jezia

Organic compounds -- part of the class 532-570 series

Organic compounds

514 44, 514419, 536 253, 536 2532, 5462701, 5462711, 5483111, 5483124, C07D29300, C07D41700, C07H 2100, A01N 4304

Patent

active

060841028

ABSTRACT:
Minor groove binding molecules are covalently bound to oligonucleotides which in their base sequence are complementary to a target sequence of single stranded or double stranded DNA, RNA or hybrids thereof. The covalently bound oligonucleotide minor groove binder conjugates strongly bind to the target sequence of the complementary strand.

REFERENCES:
patent: 4835263 (1989-05-01), Nguyen et al.
patent: 5237101 (1993-08-01), Nicolaou et al.
patent: 5395849 (1995-03-01), Wittman et al.
patent: 5419966 (1995-05-01), Reed et al.
patent: 5446137 (1995-08-01), Magg et al.
Webb, T. R. & Matteucci, M.D. (1986) Nucleic Acids Res., 14:7661-7674.
Webb. T. R. and Matteucci, M.D. (1986) J. Am. Chem. Soc. 108:2764.
Kazimierczuk et al. (1984) J. Am. Chem. Soc., 106:6376-6382.
Robins et al. (1982) Can. J. Chem., 60:554.
Robins et al. (1983) J. Org. Chem., 48:1854.
Sonveaux, (1986) Bioorganic Chemistry, 14:274-325.
Jones, (1984) Oligonucleotide Synthesis, a Practical Approach, M.J. Gait, Ed., Oxford, UK:IRL Press p. 23-24.
Gibson, K. J. & Benkovic, S. J. (1987) Nucleic Acids Res., 15:6455.
Boger, D. L., Coleman, R. S. and Invergo, B. J., (1987) J. Org. Chem.,52:1521-1530.
Grehn, L. and Ragnarsson, V. (1981) J. Org. Chem., 46:3492-3497.
Orum et al. "Slot-blot hybridization assay" (1993) Nucleic Acid Research, 21:5332-5336.
Gamber, H. B. et al. (1993) Nucleic Acids Res., vol. 21 No. 1:145-150.
M. Gait (ed.), (1984) Oligonucleotide Synthesis, A Practical Approach, Gait, M. Ed., pp. 35-81.
Petrie, C. R. et al. (1992) Biconjugate Chemistry, 3:85-87.
Jost, J. P. et al. (1989) "Quantitative precipitation of short oligonucleotides with low concentrations of cetyltrimethylammonium bromide", Nucleic Acids Res., 17:2143.
Godovikova, T. S. et al. (1989) Bioorgan. Khim., 15:1246-1259.
Lokhov, S. G. et al. (1992) Bioconjugate Chem., 3:414.
Lee et al. (1994) Biochemistry, 33:6024-6030.
Larhammar, Dan et al. (1983) Proc. Natl. Acad. Sci. USA, 80:7313-7317.
Reed et al. "Acridine- and cholesterol-derivatized solid supports for improved synthesis of 3'-modified oligonucleotides" Bioconjugate chem. vol. 2, pp. 217-225, 1991.

Affiliated with

Also associated with

Rating

Covalently linked oligonucleotide minor grove binder conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Covalently linked oligonucleotide minor grove binder conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Covalently linked oligonucleotide minor grove binder conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1487789