Covalently linked N,O-carboxymethylchitosan and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 2, 514 8, 514 54, 536 20, 604 57, 424422, 424423, 424424, 424426, 424488, A61K 3173, A61F 200

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058889884

ABSTRACT:
Covalent compositions of N,O-carboxymethyl chitosan (NOCC) are disclosed. NOCC can be intra- or intermolecularly linked, either through a direct bond or through a bridging moiety. Also disclosed are methods for preparing and using the covalent NOCC compositions. The NOCC compositions are useful in the administration of therapeutically active compounds and for wound management.

REFERENCES:
patent: 4141973 (1979-02-01), Balazs
patent: 4424346 (1984-01-01), Hall et al.
patent: 4619995 (1986-10-01), Hayes
patent: 4819617 (1989-04-01), Goldberg et al.
patent: 4886787 (1989-12-01), deBelder et al.
patent: 5023090 (1991-06-01), Levin
patent: 5080893 (1992-01-01), Goldberg et al.
patent: 5093319 (1992-03-01), Higham et al.
patent: 5140016 (1992-08-01), Goldberg et al.
patent: 5411988 (1995-05-01), Bockow et al.
patent: 5412084 (1995-05-01), Elson et al.
patent: 5462990 (1995-10-01), Hubbell et al.
Buckman, R. et al., "A Physiologic Basis for the Adhension-free Healing of Deperitonealized Surfaces", Journal of Surgical Research, vol. 21, pp. 67-76 (1976);
Elikin, T. et al., "Adhension Prevention by Solutions of Sodium Carboxymethylcellulose in the rat. I", Fertility and Sterility, Vol. 41 (6), pp. 926-928 (Jun. 1984);
Elkins, T. et al., "Adhension Prevention by Solutions of Sodium Carboxymethylcellulose in the rat. II", Fertility and Sterility, vol. 41 (6), pp. 929-932 (Jun. 1984);
Fukasawa, M. et al., "Inhibition of Postsurgical Adhensions in a Standardized Rabbit Mode: II. Intraperitoneal Treatment with Heparin", Int. J. Fertil., vol. 36 (50, pp. 296-301 (1991);
Gervin, A. et al., "Serosal Hypofirnolysis", The Americal Journal of Surgery, vol. 125, pp. 80-88 (Jan. 1973);
Hemadeh, O. et al., "Prevention of Peritoneal Adhensions by Administration of Sodium Carboxymethylcellulose and Oral Vitamin E", Surgery, vol. 114, pp. 907-910 (Nov. 1993);
Horano, S. et al., "Chitin and Chitosan for use as a Novel Biomedical Material", Proceedings of the Symposium on Advances in Biomedical Polymers, pp. 285-296, 190th National American Chemistry Society Meeting in Chicago, IL held Sept. 8-15 (1985);
Holtz, G., "Prevention of Postoperative Adhensions", The Journal of Reproductive Medicine, vol. 24 (4), pp. 141-146 (Apr. 1980);
Langford, M. et al., "Effects of Healon.RTM., N, O Carboxymethyl Chitosan.RTM. and Vitreon.RTM. on Conjunctival Cells and Human Peripheral Blood Lymphocytes", Southern Biomedical Engineering Conference-Proceedings, IEEE, pp. 286-288 (1995);
Levinson, C. et al., "Postoperative Adhensions: Etiology, Prevention, and Therapy", Clinical Obsteterics and Gynecology, vol. 23 (4), pp. 1213-1220 (Dec. 1980);
Muzzarelli, R. et al., "Carboxymethylated Chitins and Chitosans", Carbonhydrate Polymers, vol. 8, pp. 1-21 (1988);
Nair, S. et al., "Role of Proteolytic Enzyme in the Prevention of Postoperative Intraperitoneal Adhensions", Arch. Surg., vol. 108, pp. 849-853 (Jun. 1974);
Pouyiani, T. et al., "Novel Hydrogels of Hyaluronic Acis: Synthesis, Surface Morphology, and Solid-State NMR", j. Am. Chem. Soc., vol. 116, pp. 7515-7522 (1994);
Rinaudo, M. et al., "Substituent Fistribution on o, N-carboxymethylchitosans by .sup.1 H and .sup.13 C n.m.r. ", Int. Journal of Biol. Macromol., vol. 14 (3), pp. 122-128 (1992);
Sahin, Y. et al., "Synergistic Effects of Carboxymethlycellulose and Low Molecular Weight Heparin in Reduction Adhension Adhension Formation in the Rat Uterine Horn Model", Acta Obstst. Gynecol. Scand., vol. 73, pp. 70-73 (1994);
Sawhney, A et al., "Optimization of Photopolymerized Bioerodible Hydrogel Properties for Adhension Prevention", Journal of Biomedical Materials Research, vol. 28 pp. 831-838 (1994);
Thompson, J. et al., "Reduced Human Peritoneal Plasminogen Activating Activity: Possible Mechanism of Adhension Formation", br. J. Surg., vol. 76, pp. 382-384 (Apr. 1989);
Yalpani, M. et al., "Some Chemical and Analytical Aspects of Polysaaccharide Modifications. .sup.1 3. Formation of Branched-Chain, Soluble chitosan Derivatives.sup.2 ", Macromolecules, vol. 17, pp. 272-281 (1984).

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