Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-08-07
1992-12-08
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530324, 530325, 530326, 530327, 530328, 530329, 530330, 530377, 5303911, 5303915, 5303917, 5303919, 530306, 530307, 530308, 530313, 530323, 530351, 530395, 530399, 530403, 530408, 530409, 530410, 424 11, 424 9, 424 8591, 435188, 514 2, 514 8, 514 12, 514 21, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, C07K 1702, C07K 706, C07K 708, C07K 710, C07K 734, C07K 736, C07K 738, A61K 4902
Patent
active
051699338
ABSTRACT:
Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.
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Abrams Paul G.
Anderson David C.
Fritzberg Alan R.
Morgan, Jr. A. Charles
Nichols Everett J.
Kim Kay K.
NeoRx Corporation
Nucker Christine M.
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