Covalently-linked complexes and methods for enhanced cytotoxicit

Details Covalently-linked complexes and methods for enhanced cytotoxicit Covalently-linked complexes and methods for enhanced cytotoxicit

1988-08-15

1992-08-04

Nucker, Christine

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 8591, 424 943, 514 8, 514 12, 514 21, 530395, 5303917, 5303897, 53028815, 5303888, 5303871, 5303913, 435188, A61K 3944, A61K 4902, A61K 4904

Patent

active

051357364

ABSTRACT:
Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein or peptide; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-membrane interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.

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