Covalently linked .beta. subunits of the glycoprotein hormones a

Details Covalently linked .beta. subunits of the glycoprotein hormones a Covalently linked .beta. subunits of the glycoprotein hormones a

1994-11-04

1998-01-06

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530397, 530398, 530399, 514 2, A61K 3824, C07K 1459

Patent

active

057054789

ABSTRACT:
Single-chain forms of the glycoprotein hormone quartet, at least some members of which are found in most vertebrates, are disclosed. The single chain compounds of the invention comprise two .beta. subunits of the glycoprotein hormones, which .beta. subunits are the same or different. These "two-.beta." forms are antagonists of glycoprotein hormone activity.

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Fares, F.A. et al.; Design of a Long-acting Follitropin Agonist by Fusing the C-terminal Sequence of the Chorionic Gonadatropin .beta. Subunit to the Follitropin .beta. Subunit; Proc Natl Acad Sci USA (1992) 89:4304-4308.
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