Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-06-21
2005-06-21
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S004300, C514S866000, C530S303000, C530S304000, C530S402000, C435S068100, C435S810000
Reexamination Certificate
active
06908897
ABSTRACT:
Provided herein is a heretofore unknown insulin analogue, a pharmaceutical composition comprising such an insulin analogue, as well as processes for preparing such an insulin analogue and such a pharmaceutical composition.
REFERENCES:
patent: WO 95/05187 (1995-02-01), None
Deppe et al., Naunyn-Schmiedenberg's Archives of Pharmacology, vol. 35, No. 2, pp. 213-217, Aug. 1994.
Leyer et al., International Journal of Peptide & Protein Research, vol. 46, No. 5, pp. 397-407, Nov. 1995.
Schuttler et al., Hoppe-Seyler's Zeistschrift Fur Physiologische Chemie, vol. 363, No. 3, 317-330, Mar. 1982.
Deppe, C. et al., “Structure-activity relationship of covalently dimerized insulin derivatives: correlation of partial agonist efficacy with cross-linkage at lysine B29,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 350, No. 2, p. 213-217 (Aug. 1994).
Leyer, Sigmar, et al., “The role of the C-terminus of the Insulin B-chain in modulating structural and functional properties of the hormone,” International Journal of Peptide & Protein Research, vol. 46, No. 5, p. 397-407 (Nov. 1995).
Shojaee-Moradie, F. et al, “Demonstration of a relatively hepatoselective effect of covalent insulin dimers on glucose metabolism in dogs,” Diabetologia, vol. 38, No. 9, p. 1007-1013.
Schüttler, A., et al., “Preparation of Properties of Covalently Linked Insulin Dimers,” Hoppe-Seyler's Zeitschrift Für Physiologische Chemie, vol. 363, No. 3, p. 317-330 (Mar. 1982).
Brandenburg Dietrich
Havenith Chantalle
Aventis Pharma Deutschland GmbH
Coppola William
Mohamed Abdel A.
Weber Jon
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