Covalently bound heparin--antithrombin-III complex

Details Covalently bound heparin--antithrombin-III complex Covalently bound heparin--antithrombin-III complex

1983-09-26

1987-08-25

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, 514822, A61K 31725, C08B 3710

Patent

active

046893237

ABSTRACT:
There is disclosed a process for producing a convalently bound heparin--antithrombin-III complex useful for anticoagulant therapy, a covalently bound heparin--antithrombin-III complex produced by the process, a composition thereof in a pharmaceutically acceptable carrier, and a method for preventing and treating thromboembolisms by administering to a human patient a therapeutically effective amount of the complex or preparation.

REFERENCES:
patent: 4301153 (1981-11-01), Rosenberg
patent: 4446126 (1984-05-01), Jordan
Bjork et al., Permanent Activation of Antithrombin by Covalent Attachment of Heparin Oligosaccharides, FEBS Letters, 143(1), pp. 96-100 (1982).
Ceustermans et al., Preparation, Characterization, and Turnover Properties of Heparin--Antithrombin III Complexes Stabilized by Covalent Bonds, J. Biol. Chem. 257(7), pp. 3401-3408 (1982).
Hoylaerts et al., Covalent Complexes Between Low Molecular Weight Heparin Fragments and Antithrombin III-Inhibition Kinetics and Turnover Parameters, Chem. Abs. 98:213439k (1983).
Miura et al., Anticoagulant Activity of Artificial Biomedical Materials with Co-Immobilized Antithrombin III and Heparin, Biochimie 62, pp. 595-601 (1980).
Jordan et al., Fractionation of Low Molecular Weight Heparin Species and Their Interaction with Antithrombin, J. Biol. Chem. 254(8), pp. 2902-2913 (1979).
Tam et al, Proc. Natl. Acad. Sci., 73 (6), 2128 (1976).
Marshall et al, J. Biol. Chem., 254(4), 1081 (1976).
Kohn et al, Enzyme Microb. Technology, 4, 161 (1982), and Biochem. Biophys. Res. Commun., 107 (3), 878 (1982).
Rao et al, Thromb. Res., 24, 181 (1981).
Bonen et al, Thromb. Res., 27, 123 (1982).
Baird et al, J. Bone Jt. Surg., 59A, 1061 (1977).
Rosenberg et al, Proc. Natl. Acad. Sci., 75 (7), 3065 (1978).
Rosenberg et al, Biochem. Biophys. Res. Commun., 86 (4), 1319 (1979).
Lam et al, Biochem. Biophys. Res. Commun., 69 (2), 570 (1976).
Hook et al, FEBS Letters 66 (1), 90 (1976).

Affiliated with

Also associated with

Rating

Covalently bound heparin--antithrombin-III complex does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Covalently bound heparin--antithrombin-III complex, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Covalently bound heparin--antithrombin-III complex will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1923089