Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1986-09-26
1989-06-27
Lusignan, Michael R.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424422, 424484, 424 59, 424 78, A61K 914, A61F 1300
Patent
active
048428680
ABSTRACT:
The invention relates to a unique set of compositions of matter characterized by including defined active agents covalently bonded to carbonium ion base groups, as well as the method of creating the compositions. The covalently bonded compositions include base groups in the nature of ketene acetals and vinyl ethers and the thio equivalents thereof. The available active agents include alcohols, phenols, carboxylic acids, thiols, amines, amides, urethanes, phosphate esters, sulfonic acids and oximes. The compositions may either be in capped form or leashed to a polymeric backbone. The compositions are ordinarily formed by self actuating reactions when the appropriate base groups and active agents are juxtaposed under proper environmental conditions. The primary uses of the compositions are in controlled release applications such as drugs, topical insecticides and the like or in any application where predictable hydrolytic release of the active agent is desirable.
REFERENCES:
patent: 4304767 (1981-12-01), Heller et al.
patent: 4532335 (1985-07-01), Helwing
patent: 4610870 (1986-09-01), Jain et al.
Hughes Michael J.
Lusignan Michael R.
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