Organic compounds -- part of the class 532-570 series – Organic compounds – Halogen containing
Reissue Patent
2008-09-17
2011-11-15
Kosson, Rosanne (Department: 1652)
Organic compounds -- part of the class 532-570 series
Organic compounds
Halogen containing
C523S500000, C548S304100, C435S018000
Reissue Patent
active
RE042931
ABSTRACT:
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
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Bulleit Robert F.
Klaubert Dieter
Los Georgyi V.
McDougall Mark
Wood Keith V.
Casimir Jones S.C.
Kosson Rosanne
Promega Corporation
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