Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1989-11-16
1990-10-09
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
435 6, 435 7, 435 28, 435188, C12N 908, C12Q 128
Patent
active
049620290
ABSTRACT:
Oligonucleotides derivatized to incorporate horseradish peroxidase (HRP) are useful in diagnostic methods and provide significant advantage over radioactively labeled oligonucleotide probes. The HRP-derivatized oligonucleotides can be easily and efficiently prepared by reacting a sulfhydryl containing oligonucleotide with a conjugate of a mal-sac-HNSA ester and HRP under mild and easily controlled reaction conditions.
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patent: 4670379 (1987-06-01), Miller
PCT Search Report issued Jan. 27, 1989.
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Jablonski, E. et al., Nucleic Acids Research 14:6115-6128 (1986).
Renz, M. et al., Nucleic Acids Research 12:3435-3445 (1984).
Ruth, J. et al., Nucleosides & Nucleotides 6:(1&2):541-542 (1987).
Beaucage, S. et al., Tetrahedron Lett. 22:1859-1862 (1981).
Connolly, B., Nucleic Acids Research 15:3131-3139 (1987).
Connolly, B., Nucleic Acids Research 13:4485-4502 (1985).
Chang Chu-An
Levenson Corey
Oakes Fred T.
Cetus Corporation
Halluin Albert P.
Kaster Kevin R.
Reed Dianne E.
Wax Robert A.
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