Covalent lock for self-assembled oligonucleotide constructs

Details Covalent lock for self-assembled oligonucleotide constructs Covalent lock for self-assembled oligonucleotide constructs

1995-08-01

1998-07-14

Arthur, Lisa B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 221, 536 231, 536 253, C07H 2104, C12Q 168

Patent

active

057806136

ABSTRACT:
A method of autoligating self-assembled oligonucleotide blocks is disclosed. The method includes the step of displacing a 5' displaceable group by a 3' thiophosphoryl group to form an --OP(O)(O.sup.-)S-- internucleoside linkage.

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