Covalent lipid-drug conjugates for drug targeting

Details Covalent lipid-drug conjugates for drug targeting Covalent lipid-drug conjugates for drug targeting

1990-11-01

1992-09-22

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424450, 514 51, 514 78, 530300, 530331, 530329, 544243, 564153, C07H 1700, A61K 3722, A61K 3170

Patent

active

051497948

ABSTRACT:
This invention relates to a novel method of drug targeting which comprises covalently binding a drug to a lipid carrier. This composition has the unique ability to both enhance the rate at which an antineoplastic or antiviral drug crosses the plasma membrane, and to direct the drug within the cell to specific organelles. The versatility of these conjugates may be further enhanced by including a spacer group between the drug and the lipid which may act to modulate drug release at the target site.

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