Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active...
Reexamination Certificate
2001-05-18
2004-03-02
Naff, David M. (Department: 1651)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
C424S093700, C435S177000, C435S178000, C435S180000, C435S235100, C435S325000, C435S371000
Reexamination Certificate
active
06699465
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Technical Field
The present invention relates generally to covalent modification of surface protein or carbohydrate for protecting an animal against viral attack.
2. Related Art
FIG. 1
illustrates a cellular cross-sectional view of viral disease pathogenesis, in accordance with the related art.
FIG. 1
shows cells
10
and
20
within an extracelluar environment
15
. The cell
10
comprises a cell interior
12
, and a nucleus
11
within the cell interior
12
. A viral receptor
14
is coupled to a membrane surface
13
of the cell
10
. The cell
20
comprises a cell interior
22
and a nucleus
21
within the cell interior
22
. A viral receptor
24
is coupled to a membrane surface
23
of the cell
20
.
An extracellular virus
1
in the extracellular environment
15
enters the cell
10
through the viral receptor
14
. While within the cell interior
12
of the cell
10
, the virus
1
undergoes multiple rounds of replication, resulting in the replication of viral DNA, RNA, and protein from viruses
2
,
3
,
4
, and
5
, which: are packaged into their envelopes to become viruses
6
,
7
,
8
, and
9
, respectively; and pass through the membrane surface
13
into the extracellular environment
15
.
The virus
9
enters the cell
20
through the viral receptor
24
. While within the cell interior
22
of the cell
20
, the virus
9
undergoes multiple rounds of replication (not shown) in the cell interior
22
of the cell
20
, and subsequently passes through the membrane surface
23
enters the extracellular environment
15
as replicated viruses
27
,
28
, and
29
.
Unfortunately, the viral replication in the cells
10
and
20
, as described supra, causes destruction of the cells
10
and
20
and possible consequent viral disease of an animal (i.e., a human or non-human animal) that comprises the cells
10
and
20
. Thus, there is a need to prevent such viral disease from occurring in the animal.
SUMMARY OF THE INVENTION
The present invention provides a chemo-physiological structure, comprising:
a membrane surface of a cell of an animal;
a viral receptor coupled to the membrane surface; and
a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
The present invention provides a method for forming a chemo-physiological structure, comprising:
providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface; and
covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
The present invention provides a chemo-physiological structure, comprising:
a virus having a capsid; and
a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
The present invention provides a method for forming a chemo-physiological structure, comprising:
providing a virus having a capsid; and
covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
The present invention prevents a virus from recognizing the viral receptors or the cell membrane of an animal cell, and thus from entering an interior portion of the cell. Accordingly, the present invention protects the animal cell against viral attack and prevents viral infection of the animal. The present invention may be used to prevent viral infection in both human animals and non-human animals.
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patent: 4147803 (1979-04-01), Asculai et al.
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patent: 4591505 (1986-05-01), Prince
patent: 4897304 (1990-01-01), Hossain et al.
patent: 4957734 (1990-09-01), Miller
patent: 5182104 (1993-01-01), Marcus et al.
patent: 5663161 (1997-09-01), Bell
patent: 5671754 (1997-09-01), Schmukler et al.
patent: 5770199 (1998-06-01), Eibl et al.
patent: 5952392 (1999-09-01), Katz et al.
Selma Mizouni, Viral Modification with Methoxypoly(Ethylene Glycol): Implication for Viral Inactivation and Gene Therapy?, Thesis, Jun. 8, 2000, pp. 1-59.
Mizouni et al., Viral Modification with Methoxypoly(Ethylene Glycol): Implications for Gene Therapy and Viral Inactivation, 1998, Blood 92 (Suppl. 1), 4627, 1 page.
Mizouni et al., Use of a Two-Phase Partitioning System to Purify an Immunologically Attenuated Viral Vector, 1999, Blood 94 (Suppl. 1) 5081 (415b), 1 page.
Albany Medical College
Naff David M.
Schmeiser Olsen & Watts
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